Basic information

Full name
cyclin dependent kinase 7
Ensembl
ENSG00000134058.12
Summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Annotation
Essential genes Druggable target (Tier T3) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.8e-36-8.2e-23---3.7e-57.4e-166e-20-2.5e-7-
protein3.1e-78-0.0144.9e-22-3.5e-196.9e-291.4e-330.322.4e-46.6e-5

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.512log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2020.52121.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CDK7 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_DNA_REPAIR2e-355.9e-40.0060.0374.8e-71.6e-66.7e-101.2e-65.2e-41.5e-34.5e-4
HALLMARK_MYC_TARGETS_V26.4e-330.0112.9e-30.142.5e-78.1e-84e-111.9e-51.2e-30.0731.4e-5
HALLMARK_E2F_TARGETS6.3e-290.0052.2e-30.0243.1e-51.1e-43.3e-89.5e-60.0881.5e-31.8e-5
KINASE-PSP_CDK11.3e-280.023-0.820.0242.2e-168.4e-82.2e-73.1e-60.265.7e-34.9e-4
HALLMARK_G2M_CHECKPOINT6.4e-260.0112.1e-32.3e-31.4e-41.2e-31.8e-72.0e-50.49.8e-47.8e-5
KINASE-PSP_CDK21.9e-240.150.0569.5e-44.9e-68.4e-99.7e-51.8e-50.570.0173.7e-5
xcell: T cell CD4+ Th21.9e-210.0920.010.0743.4e-80.0349.8e-46.6e-40.0151.1e-46.8e-4
HALLMARK_MYC_TARGETS_V15.9e-216.3e-30.0630.592.5e-42.7e-46.7e-81.9e-50.0396.5e-30.005
PERT-PSP_NOCODAZOLE8.4e-170.320.140.70.0147.4e-78.4e-88.3e-50.670.0121.4e-4
xcell: T cell CD4+ Th13.7e-162.8e-40.430.111.9e-32.0e-61.8e-61.9e-3-0.680.150.003
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CDK7

BRCA0.230.100.41proteinmRNASCNVmethylationCCRCC0.190.090.000.120.38-0.11proteinmRNASCNVmethylationCOAD0.230.050.17proteinmRNASCNVmethylationGBM0.25-0.130.12-0.090.10-0.08proteinmRNASCNVmethylationHNSCC0.310.110.07-0.110.61-0.08proteinmRNASCNVmethylationLSCC0.470.06-0.06-0.020.32-0.16proteinmRNASCNVmethylationLUAD0.310.19-0.12-0.000.240.07proteinmRNASCNVmethylationOV0.480.360.35proteinmRNASCNVmethylationPDAC0.320.17-0.000.160.430.10proteinmRNASCNVmethylationUCEC0.21-0.200.05-0.130.20-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CDK7 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.