Protein: ENSP00000256443
Gene: CDK7

LinkedOmicsKB © 2022-2023 Zhang Lab

CDK7:
cyclin dependent kinase 7

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S164GLAKSFGSPNRAYTH101340100-67539710090-9151787197897717105449518
Y169FGSPNRAYTHQVVTR814739-247--27-985554--32-9
T170GSPNRAYTHQVVTRW101230105-5639969381-794483756965831993379518
S321VETLKEQSNPALAIK748671-6141----7348456760--625916
Showing 1 to 4 of 4 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S164GLAKSFGSPNRAYTH7.8e-39--3.3e-66.7e-20-1.8e-172.2e-193e-70.0112.1e-16-0.32
Y169FGSPNRAYTHQVVTR-----------
T170GSPNRAYTHQVVTRW4.2e-27-4.3e-52e-23--4.7e-61.6e-168.3e-80.128.1e-60.17
S321VETLKEQSNPALAIK5.3e-21-3.9e-4---5.2e-142.7e-8--0.03
Showing 1 to 4 of 4 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
SETD1B mutationT1700--0.4-------0.4
HALLMARK_MYC_TARGETS_V2S1644.5e-170.030.141.9e-34.6e-33.4e-48.5e-40.025.7e-35.1e-50.36
HALLMARK_DNA_REPAIRS1646e-167.4e-40.0080.240.0035.8e-34.4e-40.0160.0987.9e-70.88
HALLMARK_E2F_TARGETSS1641.4e-120.0153.1e-38.7e-30.0130.0161.2e-30.140.983.8e-60.93
HALLMARK_MYC_TARGETS_V1S1642.6e-110.0260.30.050.0350.0241.1e-30.013-0.862.8e-50.082
HALLMARK_G2M_CHECKPOINTS1643.7e-110.0490.0224.3e-30.0120.0282.5e-30.17-0.951.1e-50.71
KINASE-PSP_CK2A1/CSNK2A1S1649e-110.740.0570.811.8e-40.0124.7e-50.120.952.9e-40.013
xcell: T cell CD4+ Th1S1647.2e-91.9e-40.211.3e-50.140.0870.0110.78-0.952.1e-3-0.94
HALLMARK_MITOTIC_SPINDLET1701.4e-70.023-0.0990.0320.210.541.3e-33.9e-60.130.0730.37
xcell: T cell CD4+ Th2S1641.4e-60.280.650.787.7e-40.140.0450.0080.871.2e-30.6
Showing 1 to 10 of 1032 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS164Y169T170S321proteinRNASCNVmethylationCCRCCS164Y169T170S321proteinRNASCNVmethylationCOADS164Y169T170S321proteinRNASCNVmethylationGBMS164Y169T170S321proteinRNASCNVmethylationHNSCCS164Y169T170S321proteinRNASCNVmethylationLSCCS164Y169T170S321proteinRNASCNVmethylationLUADS164Y169T170S321proteinRNASCNVmethylationOVS164Y169T170S321proteinRNASCNVmethylationPDACS164Y169T170S321proteinRNASCNVmethylationUCECS164Y169T170S321proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
CDK7S1646.7e-402.0e-53.7e-56.9e-33.9e-72.2e-164.5e-70.0177.7e-52.2e-60.18
PRKDCS1642.2e-191.3e-44.4e-30.412.4e-41.9e-31.1e-30.0377.1e-35.1e-70.26
CDK7T1702.7e-171.4e-50.110.0210.0190.164.3e-63.6e-60.950.0554.5e-4
TRRAPS1641.2e-157.7e-40.244.6e-53.5e-41.1e-37.5e-40.280.231.6e-30.3
VRK1S1643.2e-151.1e-30.0964.1e-76.0e-40.0170.030.610.182.6e-60.7
BAZ1BS1642.2e-140.0222.1e-31.6e-61.4e-60.091.7e-3-0.130.227.6e-7-0.73
CDK1S1642e-130.0526.3e-31.1e-44.7e-31.1e-40.010.380.661.7e-6-0.49
CDK12S1648.1e-131.1e-35.7e-40.321.4e-61.2e-41.2e-30.560.210.039-0.38
BAZ1AS1641.5e-113.3e-30.230.0152.1e-70.0290.0150.74-9.7e-40.81
CDK9S1641.1e-104.7e-40.080.0292.9e-30.0090.024-0.390.0325.3e-30.29
Showing 1 to 10 of 2152 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TNS2S164-1.3e-15-0.03-0.055-2.2e-16-0.031-9.4e-5-4.5e-3-0.081-0.17-0.150.61
LHPPS164-7.3e-15-0.062-0.12-4e-9-5.1e-4-1.1e-7-0.120.71-0.9-1.4e-5-0.4
PHPT1S164-6.3e-10-0.59-0.71-5e-7-9.1e-3-3.0e-4-0.003-0.620.33-1.6e-4-0.26
TAB1S164-6.6e-10-3.8e-8-0.17--0.18-0.058--0.21-0.13-6.2e-70.72
HDHD2S164-8.3e-10-0.1-0.47-0.38-3.6e-4-5.2e-6-2.5e-40.940.82-5.0e-4-0.23
PUDPT170-1.7e-9-0.12-0.37-0.4-0.015-0.024-0.022-2.2e-3-0.03-0.38-7.9e-3
PPP3CAS164-7.5e-9-0.0480.11-0.018-2.4e-5-6.8e-6-3.5e-30.76--3.7e-40.77
PDXPS164-9.6e-9-0.023-0.18-4.9e-4-4.2e-6-0.027-0.670.950.45-2.9e-5-0.65
PPM1KT170-9.7e-9-0.09-0.23--0.016-0.81-1.1e-5-0.0110.8-1.8e-4-0.22
IMPA1S164-5.5e-8-0.15-0.59-7.3e-6-4.3e-5-0.096-0.050.140.45-2.1e-5-0.33
Showing 1 to 10 of 960 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.