Basic information

Full name
catenin beta 1
Ensembl
ENSG00000168036.18
Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Annotation
Cancer driver (Oncogene)

Protein product

  • ENST00000349496.11 Primary ENSP00000344456.5 (24 phosphosites)
  • ENST00000645320.1
  • ENST00000441708.2
  • ENST00000396185.8
  • ENST00000433400.6
  • ENST00000643297.1
  • ENST00000643541.1
  • ENST00000396183.7
  • ENST00000643031.1
  • ENST00000645210.1
  • ENST00000642992.1
  • ENST00000644867.1
  • ENST00000643977.1
  • ENST00000642315.1
  • ENST00000643992.1
  • ENST00000647390.1
  • ENST00000645982.1
  • ENST00000642248.1
  • ENST00000450969.6
  • ENST00000431914.6
  • ENST00000646725.1
  • ENST00000642426.1
  • ENST00000405570.6
  • ENST00000646369.1
  • ENST00000645276.1
  • ENST00000644873.1
  • ENST00000644524.1
  • ENST00000644678.1
  • ENST00000645900.1
  • ENST00000646381.1
  • ENST00000642836.1
  • ENST00000645493.1
  • ENST00000453024.6
  • ENST00000646174.1
  • ENST00000646116.1
  • ENST00000647264.1
  • ENST00000642886.1
  • ENST00000642986.1
  • ENST00000644138.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA5.5e-7-4.1e-4---0.41-3.6e-31.9e-13-5.5e-5-
protein-8.6e-4--1.4e-142e-9--9.9e-7-6e-7-4.7e-68.6e-50.0130.74

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC11.51212.51313.51414.51515.516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.529log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CTNNB1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)1e-26-3.8e-5--2.9e-61.5e-31.2e-7-3.7e-46.8e-8
Tumor Purity (ABSOLUTE)3.3e-19-0.289.1e-41.4e-4-1.7e-59.9e-60.0012.4e-30.0954.1e-5
chromosomal instability1.5e-120.022-0.923.2e-6-4.8e-42.2e-41.3e-33.1e-30.026-0.22
KINASE-PSP_AMPKA1/PRKAA13.1e-11--------2.2e-160.24
HALLMARK_PEROXISOME1e-80.310.0310.12-2.6e-30.182.1e-40.140.240.083
HALLMARK_WNT_BETA_CATENIN_SIGNALING2.6e-60.960.63.8e-4-0.510.038-0.44-0.430.562.2e-16
HALLMARK_BILE_ACID_METABOLISM4.3e-60.454.8e-40.31-0.053-0.0881.3e-50.0720.470.16
cibersort: Myeloid dendritic cell activated8.4e-60.20.0220.018-0.0490.229.3e-30.960.890.15
PROGENy: p532.7e-4-0.50.19-0.015-7.2e-52.4e-30.048-0.134.4e-30.017
PROGENy: VEGF9.8e-40.330.28-0.61-0.141.3e-30.0270.66-0.730.18
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CTNNB1

BRCA0.140.190.48proteinmRNASCNVmethylationCCRCC0.200.03-0.360.060.06-0.26proteinmRNASCNVmethylationCOAD0.380.260.22proteinmRNASCNVmethylationGBM-0.090.230.05proteinmRNASCNVmethylationHNSCC0.210.13-0.09-0.230.17-0.20proteinmRNASCNVmethylationLSCC0.140.12-0.19-0.320.44-0.32proteinmRNASCNVmethylationLUAD0.080.06-0.190.060.22-0.17proteinmRNASCNVmethylationOV0.340.260.60proteinmRNASCNVmethylationPDAC0.270.160.10-0.050.510.02proteinmRNASCNVmethylationUCEC0.10-0.06-0.080.120.10-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CTNNB1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.