Gene: DAB2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
DAB adaptor protein 2
Ensembl
ENSG00000153071.15
Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.1e-39--9.8e-5---0.043-2.7e-26-7.5e-22--1.2e-3-
protein-6.5e-48--1.3e-25-7.5e-10--1.8e-6-9.2e-20-6.5e-9-9.6e-44.6e-6-8.7e-10

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC22.52323.52424.52525.52626.52727.52828.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035400-5-10-15-20-25-30-35-40Pan-cancer0204060801001201401600-20-40-60-80-100-120-140-160proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DAB2 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: StromalScore2.5e-1002.2e-16-0.0281.6e-42.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-16
ESTIMATE: ESTIMATEScore1.7e-852.2e-16-0.112.6e-32.2e-162.2e-162.2e-162.2e-161.8e-91.2e-72.2e-16
xcell: microenvironment score3.3e-699.2e-7-0.124.4e-32.2e-166.5e-102.2e-162.2e-161.5e-62.7e-82.2e-16
HALLMARK_KRAS_SIGNALING_UP2.4e-542.2e-16-0.0614.0e-42.2e-161.2e-62.2e-165.6e-64.3e-99.8e-52.8e-4
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION9.9e-542.2e-16-4.7e-46.2e-42.2e-162.5e-72.2e-160.0012.2e-169.9e-52.2e-4
HALLMARK_COAGULATION2.6e-514.3e-100.316.9e-42.2e-167.8e-72.2e-161.2e-32.2e-160.88.6e-5
PROGENy: TGFb3.7e-502.2e-16-0.0268.1e-41.7e-103.6e-102.2e-160.112.2e-162.3e-60.018
xcell: stroma score5.5e-498.9e-9-0.112.2e-57.1e-52.7e-102.2e-166.1e-69.5e-87.5e-81.2e-5
xcell: Macrophage M24.1e-481.3e-34.4e-50.0442.2e-162.2e-169e-173.3e-60.119.8e-31.3e-3
ESTIMATE: ImmuneScore2.4e-467.8e-4-0.380.22.2e-161.6e-72.2e-162.2e-168.8e-65.9e-42.2e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DAB2

BRCA0.810.05-0.04proteinmRNASCNVmethylationCCRCC0.71-0.050.18-0.100.38-0.12proteinmRNASCNVmethylationCOAD0.670.210.36proteinmRNASCNVmethylationGBM0.94-0.04-0.16-0.10-0.12-0.04proteinmRNASCNVmethylationHNSCC0.840.08-0.200.10-0.20-0.01proteinmRNASCNVmethylationLSCC0.910.03-0.04-0.02-0.03-0.20proteinmRNASCNVmethylationLUAD0.80-0.02-0.10-0.02-0.100.22proteinmRNASCNVmethylationOV0.690.01-0.01proteinmRNASCNVmethylationPDAC0.72-0.05-0.01-0.11-0.03-0.14proteinmRNASCNVmethylationUCEC0.88-0.170.01-0.30-0.090.21proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DAB2 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.