DDX3X: DEAD-box helicase 3 X-linked
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2i4i chain A
2jgn chain A
2jgn chain B
2jgn chain C
3jrv chain C
3jrv chain D
3jrv chain E
4o2c chain C
4o2e chain C
4o2e chain F
4o2f chain C
4o2f chain F
4px9 chain A
4px9 chain B
4px9 chain C
4pxa chain A
5e7i chain A
5e7i chain B
5e7i chain C
5e7j chain A
5e7m chain A
6cz5 chain A
6o5f chain A
6o5f chain B
7liu chain A
7liu chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S57 KGFYDKDS SGWSSSK 2 37 - - - - - - 9 - - - - - - - - - - - 23 5 S58 GFYDKDSS GWSSSKD 1 13 - - - - - - - - - - - - - - - - - - 13 - S61 DKDSSGWS SSKDKDA 7 167 38 - 13 10 - - 9 - - - 28 27 12 11 - - 4 1 14 - S62 KDSSGWSS SKDKDAY 8 724 41 - 46 36 - - 81 - 92 51 55 51 58 52 - - 58 22 63 18 S63 DSSGWSSS KDKDAYS 8 680 58 - 20 12 - - 99 - 82 46 83 76 16 16 - - 49 21 84 18 S74 DAYSSFGS RSDSRGK 1 8 8 - - - - - - - - - - - - - - - - - - - S76 YSSFGSRS DSRGKSS 1 24 24 - - - - - - - - - - - - - - - - - - - S82 RSDSRGKS SFFSDRG 8 553 - - - - 64 70 90 - 26 12 15 15 4 4 34 9 83 36 76 15 S83 SDSRGKSS FFSDRGS 9 353 - - 8 8 18 18 53 - 16 10 10 9 8 8 41 9 42 16 65 14 S86 RGKSSFFS DRGSGSR 3 54 17 - 15 5 - - - - - - - - 9 8 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S57 KGFYDKDS SGWSSSK - - - - - - - - - - - S58 GFYDKDSS GWSSSKD - - - - - - - - - - - S61 DKDSSGWS SSKDKDA 1.8e-12 - - - - - 1.8e-12 - - - - S62 KDSSGWSS SKDKDAY 6.8e-13 - -0.66 - - 2.8e-9 2.0e-6 8e-15 - -0.059 0.14 S63 DSSGWSSS KDKDAYS 2.2e-3 - 1.7e-4 - - 5.9e-5 0.027 - - -0.065 -0.19 S74 DAYSSFGS RSDSRGK - - - - - - - - - - - S76 YSSFGSRS DSRGKSS - - - - - - - - - - - S82 RSDSRGKS SFFSDRG -9.2e-4 - - -1.5e-3 - 0.28 - - - -1.1e-3 -0.2 S83 SDSRGKSS FFSDRGS -0.035 - - - - - - - - -0.069 -0.25 S86 RGKSSFFS DRGSGSR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S57
S58
S61
S62
S63
S74
S76
S82
S83
S86
S90
S92
S102
S109
S114
S131
T171
S183
S240
Y243
S429
S543
S590
S591
S594
S605
S606
S609
S610
S611
S612
S614
S615
S616
S619
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation CCRCC S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation COAD S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation GBM S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation HNSCC S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation LSCC S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation LUAD S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation OV S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation PDAC S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation UCEC S57 S58 S61 S62 S63 S74 S76 S82 S83 S86 S90 S92 S102 S109 S114 S131 T171 S183 S240 Y243 S429 S543 S591 S594 S605 S606 S609 S610 S611 S612 S614 S615 S616 S619 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S57
S58
S61
S62
S63
S74
S76
S82
S83
S86
S90
S92
S102
S109
S114
S131
T171
S183
S240
Y243
S429
S543
S590
S591
S594
S605
S606
S609
S610
S611
S612
S614
S615
S616
S619
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S57
S58
S61
S62
S63
S74
S76
S82
S83
S86
S90
S92
S102
S109
S114
S131
T171
S183
S240
Y243
S429
S543
S590
S591
S594
S605
S606
S609
S610
S611
S612
S614
S615
S616
S619
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.