Basic information
- Full name
- dual specificity tyrosine phosphorylation regulated kinase 2
- Ensembl
- ENSG00000127334.11
- Summary
- DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
- Annotation
- IDG target Druggable target (Tier T3) Protein Kinase
Protein product
- ENST00000344096.4 Primary ENSP00000342105.4 (7 phosphosites)
- ENST00000393555.3
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 4.6e-52 | - | 1.6e-22 | - | - | 9.1e-3 | 9.5e-25 | 1.2e-11 | - | 6.2e-6 | - |
protein | 1.9e-3 | - | - | - | - | - | 1.9e-3 | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of DYRK2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK5 | 0.026 | - | - | - | - | - | 0.047 | - | - | - | 0.25 | |
DISEASE-PSP_Alzheimer's_disease | 0.094 | - | - | - | - | - | - | - | - | - | 0.094 | |
cibersort: Monocyte | 0.16 | - | - | - | - | - | 0.73 | - | 0.16 | - | 0.48 | |
KINASE-PSP_PKCA/PRKCA | 0.16 | - | - | - | - | - | 0.45 | - | 0.37 | - | 0.43 | |
xcell: Macrophage M2 | 0.17 | - | - | - | - | - | 0.51 | - | 0.47 | - | 0.31 | |
HALLMARK_HEDGEHOG_SIGNALING | 0.22 | - | - | - | - | - | 0.18 | - | -0.29 | - | 0.066 | |
xcell: Cancer associated fibroblast | 0.24 | - | - | - | - | - | 0.053 | - | -0.37 | - | 0.31 | |
PROGENy: TGFb | 0.26 | - | - | - | - | - | 0.17 | - | -0.29 | - | 0.1 | |
cibersort: Macrophage M2 | 0.27 | - | - | - | - | - | 0.48 | - | 0.58 | - | 0.52 | |
KINASE-PSP_p90RSK/RPS6KA1 | 0.27 | - | - | - | - | - | - | - | - | - | 0.27 |
Cis-association
Associations between omics data of DYRK2
Trans-association
Associations of the protein abundance of DYRK2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.