Basic information

Full name
dual specificity tyrosine phosphorylation regulated kinase 2
Ensembl
ENSG00000127334.11
Summary
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Annotation
IDG target Druggable target (Tier T3) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.6e-52-1.6e-22--9.1e-39.5e-251.2e-11-6.2e-6-
protein1.9e-3-----1.9e-3----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCALSCCLUADOVPDACUCEC13.51414.51515.51616.51717.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer012345678910110-1-2-3-4-5-6-7-8-9-10-11proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DYRK2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK50.026-----0.047---0.25
DISEASE-PSP_Alzheimer's_disease0.094---------0.094
cibersort: Monocyte0.16-----0.73-0.16-0.48
KINASE-PSP_PKCA/PRKCA0.16-----0.45-0.37-0.43
xcell: Macrophage M20.17-----0.51-0.47-0.31
HALLMARK_HEDGEHOG_SIGNALING0.22-----0.18--0.29-0.066
xcell: Cancer associated fibroblast0.24-----0.053--0.37-0.31
PROGENy: TGFb0.26-----0.17--0.29-0.1
cibersort: Macrophage M20.27-----0.48-0.58-0.52
KINASE-PSP_p90RSK/RPS6KA10.27---------0.27
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DYRK2

BRCA0.23proteinmRNASCNVmethylationCCRCC-0.050.21-0.14proteinmRNASCNVmethylationCOAD0.41proteinmRNASCNVmethylationGBM-0.160.24-0.12proteinmRNASCNVmethylationHNSCC-0.130.36-0.23proteinmRNASCNVmethylationLSCC0.760.280.28-0.080.47-0.07proteinmRNASCNVmethylationLUAD-0.200.54-0.22proteinmRNASCNVmethylationOV0.570.340.55proteinmRNASCNVmethylationPDAC-0.060.37-0.12proteinmRNASCNVmethylationUCEC0.06-0.25-0.57-0.180.23-0.17proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DYRK2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.