Basic information

Full name
ELAV like RNA binding protein 1
Ensembl
ENSG00000066044.15
Summary
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.4e-29--2.6e-3--1.2e-137e-244.1e-19-0.095-
protein3.2e-59-3.2e-95.5e-26-3.2e-43.6e-249.4e-181.6e-70.026-0.72

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.529log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ELAVL1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
chromosomal instability1.6e-289.7e-60.120.0052.3e-44.9e-72.2e-164.8e-43.1e-40.024-0.99
Tumor Purity (ABSOLUTE)1.5e-277.7e-30.578.9e-56.9e-93.1e-73.3e-120.0355.5e-30.0130.046
Tumor Purity (WGS)1.8e-21-0.81-3.1e-135.8e-45.1e-145.6e-3-0.0710.035
HALLMARK_E2F_TARGETS5.5e-176.1e-70.610.596.2e-80.0162.2e-160.30.023-0.440.058
HALLMARK_G2M_CHECKPOINT1.2e-151.2e-40.047-0.862.1e-60.0162.2e-160.490.057-0.550.021
HALLMARK_SPERMATOGENESIS1.3e-152.5e-40.480.320.0112.0e-42.2e-160.286.3e-5-0.170.078
KINASE-PSP_CDK22.5e-152.8e-40.0122.9e-36.5e-70.419.1e-40.26.3e-3-0.631.2e-3
HALLMARK_MYC_TARGETS_V26.6e-158.6e-70.870.488.4e-50.272.2e-160.541.3e-6-0.230.18
xcell: T cell CD4+ Th17.4e-154.0e-6-0.720.0257.7e-90.091.2e-60.0220.05-0.299.8e-3
KINASE-PSP_PLK16e-12---0.0121.1e-10----0.003
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ELAVL1

BRCA0.400.160.18proteinmRNASCNVmethylationCCRCC0.170.040.05-0.200.08-0.03proteinmRNASCNVmethylationCOAD0.210.220.23proteinmRNASCNVmethylationGBM0.55-0.110.18-0.050.33-0.11proteinmRNASCNVmethylationHNSCC0.38-0.110.21-0.020.16-0.08proteinmRNASCNVmethylationLSCC0.76-0.410.33-0.350.46-0.34proteinmRNASCNVmethylationLUAD0.350.030.200.060.45-0.17proteinmRNASCNVmethylationOV0.380.450.50proteinmRNASCNVmethylationPDAC0.230.240.01-0.000.41-0.22proteinmRNASCNVmethylationUCEC0.36-0.10-0.11-0.290.11-0.18proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ELAVL1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.