Basic information

Full name
cyclin G associated kinase
Ensembl
ENSG00000178950.17
Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Annotation
Essential genes Protein Kinase Phosphatase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-3.1e-11--1.8e-25---4.1e-9-1.8e-51.1e-5-0.17-
protein-0.14--8.7e-300.12--0.024-0.177.4e-212.9e-3-0.257.9e-6

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2424.224.424.624.82525.225.425.625.82626.226.4log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GAK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM5.2e-115.3e-70.0190.13-0.920.670.0340.50.0150.0046.1e-4
xcell: T cell CD4+ effector memory1.6e-90.421.6e-30.091-0.512.5e-89.5e-40.390.250.630.006
HALLMARK_FATTY_ACID_METABOLISM3.5e-82.0e-40.143.8e-41-0.46-0.110.0060.0356.7e-36.2e-4
HALLMARK_PEROXISOME9e-82.7e-90.140.280.33-0.30.460.130.110.0478.1e-3
PERT-P100-DIA_STAUROSPORINE9.2e-80.48--0.520.0240.10.16-3.7e-48.7e-5
xcell: Macrophage M21.1e-74.8e-31.3e-3-0.110.0411.5e-42.7e-30.310.430.780.15
xcell: T cell CD8+ central memory9.5e-7-0.511.8e-40.90.225.5e-41.3e-70.860.420.550.45
xcell: immune score1.0e-6-0.661.3e-50.790.841.3e-69.4e-60.930.56-0.380.045
HALLMARK_INTERFERON_ALPHA_RESPONSE2.1e-6-0.619.0e-40.2-0.473.7e-52.8e-50.430.028-0.660.44
xcell: B cell2.2e-6-0.511.8e-30.150.0879.9e-55.0e-6-0.180.31-0.930.2
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GAK

BRCA0.460.430.41proteinmRNASCNVmethylationCCRCC0.390.040.14-0.290.34-0.09proteinmRNASCNVmethylationCOAD0.320.440.17proteinmRNASCNVmethylationGBM0.300.040.02-0.110.15-0.18proteinmRNASCNVmethylationHNSCC0.73-0.120.62-0.230.66-0.27proteinmRNASCNVmethylationLSCC0.76-0.410.73-0.280.73-0.28proteinmRNASCNVmethylationLUAD0.62-0.100.59-0.120.57-0.18proteinmRNASCNVmethylationOV0.320.510.58proteinmRNASCNVmethylationPDAC0.37-0.100.25-0.260.03-0.07proteinmRNASCNVmethylationUCEC0.52-0.030.10-0.140.19-0.00proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GAK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.