Basic information
- Full name
- cyclin G associated kinase
- Ensembl
- ENSG00000178950.17
- Summary
- In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
- Annotation
- Essential genes Protein Kinase Phosphatase
Protein product
- ENST00000314167.9 Primary ENSP00000314499.4 (42 phosphosites)
- ENST00000511163.5
- ENST00000618573.4
- ENST00000628912.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -3.1e-11 | - | -1.8e-25 | - | - | -4.1e-9 | -1.8e-5 | 1.1e-5 | - | 0.17 | - |
protein | -0.14 | - | -8.7e-30 | 0.12 | - | -0.024 | -0.17 | 7.4e-21 | 2.9e-3 | -0.25 | 7.9e-6 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of GAK with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_BILE_ACID_METABOLISM | 5.2e-11 | 5.3e-7 | 0.019 | 0.13 | -0.92 | 0.67 | 0.034 | 0.5 | 0.015 | 0.004 | 6.1e-4 | |
xcell: T cell CD4+ effector memory | 1.6e-9 | 0.42 | 1.6e-3 | 0.091 | -0.51 | 2.5e-8 | 9.5e-4 | 0.39 | 0.25 | 0.63 | 0.006 | |
HALLMARK_FATTY_ACID_METABOLISM | 3.5e-8 | 2.0e-4 | 0.14 | 3.8e-4 | 1 | -0.46 | -0.11 | 0.006 | 0.035 | 6.7e-3 | 6.2e-4 | |
HALLMARK_PEROXISOME | 9e-8 | 2.7e-9 | 0.14 | 0.28 | 0.33 | -0.3 | 0.46 | 0.13 | 0.11 | 0.047 | 8.1e-3 | |
PERT-P100-DIA_STAUROSPORINE | 9.2e-8 | 0.48 | - | - | 0.52 | 0.024 | 0.1 | 0.16 | - | 3.7e-4 | 8.7e-5 | |
xcell: Macrophage M2 | 1.1e-7 | 4.8e-3 | 1.3e-3 | -0.11 | 0.041 | 1.5e-4 | 2.7e-3 | 0.31 | 0.43 | 0.78 | 0.15 | |
xcell: T cell CD8+ central memory | 9.5e-7 | -0.51 | 1.8e-4 | 0.9 | 0.22 | 5.5e-4 | 1.3e-7 | 0.86 | 0.42 | 0.55 | 0.45 | |
xcell: immune score | 1.0e-6 | -0.66 | 1.3e-5 | 0.79 | 0.84 | 1.3e-6 | 9.4e-6 | 0.93 | 0.56 | -0.38 | 0.045 | |
HALLMARK_INTERFERON_ALPHA_RESPONSE | 2.1e-6 | -0.61 | 9.0e-4 | 0.2 | -0.47 | 3.7e-5 | 2.8e-5 | 0.43 | 0.028 | -0.66 | 0.44 | |
xcell: B cell | 2.2e-6 | -0.51 | 1.8e-3 | 0.15 | 0.087 | 9.9e-5 | 5.0e-6 | -0.18 | 0.31 | -0.93 | 0.2 |
Cis-association
Associations between omics data of GAK
Trans-association
Associations of the protein abundance of GAK and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.