GAK: cyclin G associated kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4c57 chain A
4c57 chain B
4c58 chain A
4c59 chain A
4o38 chain A
4o38 chain B
4y8d chain A
4y8d chain B
5y7z chain A
5y7z chain B
5y80 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S6 __MSLLQS ALDFLAG 1 20 - - - - - - - - 13 7 - - - - - - - - - - S16 DFLAGPGS LGGASGR 1 20 - - - - - - - - 13 7 - - - - - - - - - - S26 GASGRDQS DFVGQTV 1 8 - - - - - - - - - - - - - - - - - - 8 - S73 YALKRLLS NEEEKNR 10 1004 79 - 87 80 5 4 72 - 48 27 98 90 92 84 19 5 84 33 79 18 Y201 SATTISHY PDYSWSA 1 8 - - - - - - - - - - - - 4 4 - - - - - - S326 ARNVNPKS PITELLE 5 401 - - - - - - 72 - 7 3 34 33 77 68 - - - - 89 18 T329 VNPKSPIT ELLEQNG 3 42 14 - - - - - - - - - 10 9 5 4 - - - - - - S340 EQNGGYGS ATLSRGP 2 36 - - - - - - - - - - - - - - 7 2 - - 24 3 S356 PPVGPAGS GYSGGLA 1 8 - - 4 4 - - - - - - - - - - - - - - - - S359 GPAGSGYS GGLALAE 7 140 9 - 11 11 - - 18 - 5 3 5 4 35 32 - - - - 7 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S6 __MSLLQS ALDFLAG - - - - - - - - - - - S16 DFLAGPGS LGGASGR - - - - - - - - - - - S26 GASGRDQS DFVGQTV - - - - - - - - - - - S73 YALKRLLS NEEEKNR 1e-15 - -0.22 - - 0.095 7.4e-6 1.1e-12 - 1.5e-3 9.0e-6 Y201 SATTISHY PDYSWSA - - - - - - - - - - - S326 ARNVNPKS PITELLE 0.75 - - - - - -0.32 -0.11 - - 1.6e-3 T329 VNPKSPIT ELLEQNG - - - - - - - - - - - S340 EQNGGYGS ATLSRGP - - - - - - - - - - - S356 PPVGPAGS GYSGGLA - - - - - - - - - - - S359 GPAGSGYS GGLALAE 0.045 - - - - - - 0.045 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S6
S16
S26
S73
Y201
S326
T329
S340
S356
S359
S463
S760
S770
T776
S778
S780
S783
S789
T794
S811
S812
S815
S817
S826
S829
S834
S837
S905
S906
T908
S912
S922
S931
S939
S945
T949
S1091
S1096
S1154
S1168
S1176
S1185
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation CCRCC S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation COAD S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation GBM S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation HNSCC S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation LSCC S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation LUAD S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation OV S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation PDAC S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation UCEC S6 S16 S26 S73 Y201 S326 T329 S340 S356 S359 S463 S760 S770 T776 S778 S780 S783 S789 T794 S811 S812 S815 S817 S826 S829 S834 S837 S905 S906 T908 S912 S922 S931 S939 S945 T949 S1091 S1096 S1154 S1168 S1176 S1185 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S6
S16
S26
S73
Y201
S326
T329
S340
S356
S359
S463
S760
S770
T776
S778
S780
S783
S789
T794
S811
S812
S815
S817
S826
S829
S834
S837
S905
S906
T908
S912
S922
S931
S939
S945
T949
S1091
S1096
S1154
S1168
S1176
S1185
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S6
S16
S26
S73
Y201
S326
T329
S340
S356
S359
S463
S760
S770
T776
S778
S780
S783
S789
T794
S811
S812
S815
S817
S826
S829
S834
S837
S905
S906
T908
S912
S922
S931
S939
S945
T949
S1091
S1096
S1154
S1168
S1176
S1185
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.