Basic information

Full name
glycoprotein Ib platelet subunit alpha
Ensembl
ENSG00000185245.8
Summary
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
Annotation
Receptor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-4.9e-29--6.5e-21---1.0e-4-9.9e-4-1.1e-4--4.6e-6-
protein-3.7e-41-3.1e-3---7.5e-8-3.1e-33-1.7e-33-7.7e-6-0.41-1.7e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC11.522.533.544.555.566.577.58log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC17181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012140-2-4-6-8-10-12-14Pan-cancer0246810121416180-2-4-6-8-10-12-14-16-18proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GP1BA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_TNFA_SIGNALING_VIA_NFKB7.4e-190.0020.026-1.3e-33.2e-31.8e-70.0452.5e-33.2e-30.053
HALLMARK_HYPOXIA7.4e-171.9e-43.3e-4-3.4e-40.145.6e-30.0150.0392.8e-30.018
xcell: Endothelial cell9e-150.020.45-0.0160.0144.7e-72.7e-50.0150.0170.22
cibersort: Neutrophil3.3e-130.059.9e-3-8.9e-64.3e-32.0e-40.394.5e-30.160.24
PROGENy: TNFa7.1e-131.9e-30.6-6.4e-40.0356.4e-60.194.3e-39.2e-30.28
HALLMARK_KRAS_SIGNALING_UP8.9e-139.4e-40.083-3.8e-40.0365.9e-60.050.030.20.42
PROGENy: NFkB2e-121.6e-30.55-1.5e-30.0355.4e-60.282.5e-30.0250.24
PERT-PSP_EGF5.3e-122.5e-30.008-6.0e-56.0e-50.330.377.5e-40.0960.92
xcell: Monocyte2.5e-111.3e-3-0.87-1.8e-50.0034.1e-60.640.0410.0850.38
HALLMARK_INFLAMMATORY_RESPONSE6e-118.6e-4-0.94-2.2e-30.0791.6e-60.0620.0390.090.26
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GP1BA

BRCA-0.060.170.11proteinmRNASCNVmethylationCCRCC-0.050.260.22proteinmRNASCNVmethylationCOAD0.31proteinmRNASCNVmethylationGBM-0.120.230.14proteinmRNASCNVmethylationHNSCC-0.140.050.24proteinmRNASCNVmethylationLSCC-0.250.010.30proteinmRNASCNVmethylationLUAD-0.180.020.16proteinmRNASCNVmethylationOV0.06-0.040.25proteinmRNASCNVmethylationPDAC-0.030.190.01proteinmRNASCNVmethylationUCEC0.250.09-0.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GP1BA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.