Basic information
- Full name
- glycoprotein Ib platelet subunit alpha
- Ensembl
- ENSG00000185245.8
- Summary
- Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
- Annotation
- Receptor
Protein product
- ENST00000329125.6 Primary ENSP00000329380.5 (7 phosphosites)
- ENST00000611961.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -4.9e-29 | - | -6.5e-21 | - | - | -1.0e-4 | -9.9e-4 | -1.1e-4 | - | -4.6e-6 | - |
protein | -3.7e-41 | - | 3.1e-3 | - | - | -7.5e-8 | -3.1e-33 | -1.7e-33 | -7.7e-6 | -0.41 | -1.7e-4 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of GP1BA with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_TNFA_SIGNALING_VIA_NFKB | 7.4e-19 | 0.002 | 0.026 | - | 1.3e-3 | 3.2e-3 | 1.8e-7 | 0.045 | 2.5e-3 | 3.2e-3 | 0.053 | |
HALLMARK_HYPOXIA | 7.4e-17 | 1.9e-4 | 3.3e-4 | - | 3.4e-4 | 0.14 | 5.6e-3 | 0.015 | 0.039 | 2.8e-3 | 0.018 | |
xcell: Endothelial cell | 9e-15 | 0.02 | 0.45 | - | 0.016 | 0.014 | 4.7e-7 | 2.7e-5 | 0.015 | 0.017 | 0.22 | |
cibersort: Neutrophil | 3.3e-13 | 0.05 | 9.9e-3 | - | 8.9e-6 | 4.3e-3 | 2.0e-4 | 0.39 | 4.5e-3 | 0.16 | 0.24 | |
PROGENy: TNFa | 7.1e-13 | 1.9e-3 | 0.6 | - | 6.4e-4 | 0.035 | 6.4e-6 | 0.19 | 4.3e-3 | 9.2e-3 | 0.28 | |
HALLMARK_KRAS_SIGNALING_UP | 8.9e-13 | 9.4e-4 | 0.083 | - | 3.8e-4 | 0.036 | 5.9e-6 | 0.05 | 0.03 | 0.2 | 0.42 | |
PROGENy: NFkB | 2e-12 | 1.6e-3 | 0.55 | - | 1.5e-3 | 0.035 | 5.4e-6 | 0.28 | 2.5e-3 | 0.025 | 0.24 | |
PERT-PSP_EGF | 5.3e-12 | 2.5e-3 | 0.008 | - | 6.0e-5 | 6.0e-5 | 0.33 | 0.37 | 7.5e-4 | 0.096 | 0.92 | |
xcell: Monocyte | 2.5e-11 | 1.3e-3 | -0.87 | - | 1.8e-5 | 0.003 | 4.1e-6 | 0.64 | 0.041 | 0.085 | 0.38 | |
HALLMARK_INFLAMMATORY_RESPONSE | 6e-11 | 8.6e-4 | -0.94 | - | 2.2e-3 | 0.079 | 1.6e-6 | 0.062 | 0.039 | 0.09 | 0.26 |
Cis-association
Associations between omics data of GP1BA
Trans-association
Associations of the protein abundance of GP1BA and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.