Protein: ENSP00000329380
Gene: GP1BA

LinkedOmicsKB © 2022-2023 Zhang Lab

GP1BA:
glycoprotein Ib platelet subunit alpha

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y292DEGDTDLYDYYPEED710115-1716--8-635454--135--
Y294GDTDLYDYYPEEDTE710115-1716--8-635454--135--
Y295DTDLYDYYPEEDTEG5546-1312--8---54----51--
S608SLPTFRSSLFLWVRP19------------54------
S629LVAGRRPSALSQGRG9105096-9168959372-101594944595675185321--
S632GRRPSALSQGRGQDL858396-9168141318-----868172847718
S644QDLLSTVSIRYSGHS16----------------42--
Showing 1 to 7 of 7 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y292DEGDTDLYDYYPEED-----------
Y294GDTDLYDYYPEEDTE-----------
Y295DTDLYDYYPEEDTEG-----------
S608SLPTFRSSLFLWVRP-----------
S629LVAGRRPSALSQGRG-9.5e-3-1.4e-40.25-0.011-4.6e-4-3.7e-13-9.8e-3-0.31-
S632GRRPSALSQGRGQDL-3e-9-1.4e-4-----3.2e-24---8.3e-5
S644QDLLSTVSIRYSGHS-----------
Showing 1 to 7 of 7 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_TNFA_SIGNALING_VIA_NFKBS6291.1e-115.7e-40.0162.2e-50.14.2e-40.0550.270.640.098-
HALLMARK_UV_RESPONSE_UPS6299.9e-90.0427.5e-38.2e-50.160.0143.1e-30.80.230.76-
PROGENy: EGFRS6294.5e-82.9e-34.2e-31.8e-50.192.6e-40.290.130.9-0.17-
HALLMARK_UV_RESPONSE_UPS6327e-80.0427.5e-30.520.057--0.02--2.9e-4
HALLMARK_TNFA_SIGNALING_VIA_NFKBS6321e-75.7e-40.0160.250.55--0.072--2.7e-4
PROGENy: TNFaS6291.3e-72.8e-40.0465.5e-40.0812.5e-30.4-0.430.770.11-
PROGENy: NFkBS6291.6e-72.0e-40.0819.0e-40.120.0020.35-0.410.590.1-
PROGENy: TNFaS6324.9e-72.8e-40.0460.0520.34--0.16--0.018
cibersort: NeutrophilS6295.1e-70.0375.3e-30.0719.7e-31.8e-4-0.62-0.860.060.41-
PROGENy: EGFRS6326.8e-72.9e-34.2e-30.048-0.99--0.092--7.3e-3
Showing 1 to 10 of 1806 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAY292Y294Y295S608S629S632S644proteinRNASCNVmethylationCCRCCY292Y294Y295S608S629S632S644proteinRNASCNVmethylationCOADY292Y294Y295S608S629S632S644proteinRNASCNVmethylationGBMY292Y294Y295S608S629S632S644proteinRNASCNVmethylationHNSCCY292Y294Y295S608S629S632S644proteinRNASCNVmethylationLSCCY292Y294Y295S608S629S632S644proteinRNASCNVmethylationLUADY292Y294Y295S608S629S632S644proteinRNASCNVmethylationOVY292Y294Y295S608S629S632S644proteinRNASCNVmethylationPDACY292Y294Y295S608S629S632S644proteinRNASCNVmethylationUCECY292Y294Y295S608S629S632S644proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
FGRS6292.3e-122.0e-50.687.2e-61.4e-32.6e-40.350.0190.360.4-
FESS6299.2e-80.0030.0171.7e-40.370.565.1e-3-0.63.1e-30.85-
CLK3S6294.3e-60.0720.30.0390.147.1e-30.721.0e-4-0.480.25-
PLK1S6321.5e-50.0670.13----0.092--3.1e-4
MAP3K8S6321.6e-51.1e-30.44----0.044--9.7e-3
STRADAS6295.0e-50.0430.0180.220.0740.0680.50.370.290.76-
GRK5S6295.5e-50.260.15-0.322.6e-30.890.148.5e-40.0730.44-
GRK6S6327.8e-54.8e-3-0.9-0.42--0.047--8.1e-4
MASTLS6321.2e-40.03-0.84---0.042--9.5e-4
FGRS6321.3e-42.0e-50.680.18---0.02--0.82
Showing 1 to 10 of 3766 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPP1CBS629-2.3e-60.67-0.31-0.083-7.8e-5-0.064-0.390.85-2.1e-4-0.093-
BPNT1S632-3.7e-6-0.14-0.01-0.14-0.15---0.15---3.5e-3
BPNT1S629-5.6e-5-0.14-0.01-0.081-0.3-0.0660.39-0.015-0.71-0.14-
OCRLS629-6.8e-5-0.0120.73-0.054-0.120.74-1.8e-3-0.056-0.74-0.2-
PPM1JS632-1.9e-4-0.034---0.37---0.026---0.026
NT5CS632-3.7e-4-0.39-0.023-0.25-0.37---0.21---0.022
TIMM50Y294-1.1e-3-1.6e-3-0.38-------0.11-
TIMM50Y292-1.1e-3-1.6e-3-0.38-------0.11-
IMPA1S632-1.3e-3-0.058-0.002-0.84-0.7---0.52---0.1
PPM1GS629-1.5e-3-0.5-0.037-0.32-0.280.47-0.33-0.63-0.21-6.7e-3-
Showing 1 to 10 of 1680 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.