Gene: HELZ

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
helicase with zinc finger
Ensembl
ENSG00000198265.12
Summary
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.18-1.1e-14--3.9e-8-2.1e-3-0.029--5.6e-7-
protein8.1e-3-1.4e-22-0.24--9.4e-23--0.92-4.8e-7-2.8e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMLSCCLUADOVPDACUCEC1617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HELZ with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK21e-78.2e-40.0120.370.023-3.9e-31-0.90.0710.15
HALLMARK_MYC_TARGETS_V26.2e-77.0e-50.045-0.681.5e-4-1.3e-3-0.66-0.210.214.8e-3
HALLMARK_MTORC1_SIGNALING7.8e-71.9e-30.033-0.81.6e-4-0.031-0.810.150.350.071
PROGENy: PI3K9.6e-70.0470.02-0.437.1e-6--0.670.190.0310.0330.13
xcell: T cell CD4+ Th21.1e-62.2e-40.070.672.4e-4-0.840.810.740.321.3e-3
HALLMARK_G2M_CHECKPOINT1.8e-61.5e-40.110.820.015-0.410.190.693.8e-3
KINASE-PSP_CDK15.4e-67.3e-30.025-0.558.5e-5-0.15-0.730.770.0710.028
HALLMARK_DNA_REPAIR2.7e-59.0e-40.180.772.1e-4-4.3e-3-0.28-0.720.570.051
HALLMARK_UNFOLDED_PROTEIN_RESPONSE3.1e-50.0130.060.988.4e-3-4.4e-3-0.95-0.140.0140.087
HALLMARK_E2F_TARGETS6.5e-51.6e-50.3-0.754.8e-3-0.27-0.610.580.630.012
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HELZ

BRCA0.400.550.52proteinmRNASCNVmethylationCCRCC0.220.030.14-0.16-0.02-0.01proteinmRNASCNVmethylationCOAD0.360.320.31proteinmRNASCNVmethylationGBM0.32-0.230.29-0.090.50-0.14proteinmRNASCNVmethylationHNSCC0.040.140.17proteinmRNASCNVmethylationLSCC0.520.250.390.170.470.16proteinmRNASCNVmethylationLUAD0.560.240.230.660.26proteinmRNASCNVmethylationOV0.260.450.24proteinmRNASCNVmethylationPDAC0.20-0.060.340.080.550.16proteinmRNASCNVmethylationUCEC0.33-0.090.38-0.090.19-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HELZ and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.