HELZ: helicase with zinc finger
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S629 MTPTIPWS PNRQWDE 1 8 - - - - - - - - - - - - 4 4 - - - - - - S973 ELRKKRLS DVNVERV 2 31 14 - - - - - - - - - - - - - - - - - 6 11 S1119 LRLQHSGS TNKQQQS 4 94 - - - - - - 54 - - - - - 14 12 - - 3 2 7 2 S1126 STNKQQQS PPKGKSL 10 1134 91 - 45 44 12 6 99 - 76 48 108 99 106 97 48 11 92 39 95 18 T1163 GNPIRAYT PPPPLGP 10 1455 113 - 103 80 75 69 99 - 108 62 108 99 110 101 70 16 101 42 81 18 S1177 PHPNLGKS PSPVQRI 8 802 96 - 99 76 9 9 81 - - - 74 68 106 97 - - 7 3 61 16 S1179 PNLGKSPS PVQRIDP 9 786 70 - 99 76 82 79 63 - - - 20 17 29 29 75 17 37 15 65 13 S1247 LQTHGRGS PIPYGLG 5 152 - - - - - - 36 - - - 29 29 17 16 - - 15 6 4 - S1311 PKQVDLES NPQNRSP 3 28 - - 4 4 - - - - - - - - - - 7 2 8 3 - - S1317 ESNPQNRS PESRPSV 10 1490 104 - 99 76 92 96 99 - 108 62 108 99 106 97 83 19 96 40 90 16
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S629 MTPTIPWS PNRQWDE - - - - - - - - - - - S973 ELRKKRLS DVNVERV - - - - - - - - - - - S1119 LRLQHSGS TNKQQQS - - - - - - - - - - - S1126 STNKQQQS PPKGKSL 7.3e-12 - 0.14 - - 0.011 7.5e-29 1.6e-27 0.21 -6.4e-8 -1.7e-4 T1163 GNPIRAYT PPPPLGP 1.9e-51 - 4.5e-16 5e-8 - 5.2e-4 1.2e-24 1.4e-25 0.021 1.4e-5 -0.087 S1177 PHPNLGKS PSPVQRI 0.33 - 1.2e-24 - - - -1.4e-5 -0.14 - - -0.64 S1179 PNLGKSPS PVQRIDP 1.9e-19 - 1.2e-24 3.5e-12 - - 3.4e-8 -7.5e-3 0.091 8.4e-4 -0.22 S1247 LQTHGRGS PIPYGLG 4.3e-3 - - - - - 4.3e-3 - - - - S1311 PKQVDLES NPQNRSP - - - - - - - - - - - S1317 ESNPQNRS PESRPSV 5.2e-80 - 1.3e-13 1.1e-11 - 9.7e-18 3.9e-25 5.2e-27 8.4e-5 3.8e-8 0.81
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S629
S973
S1119
S1126
T1163
S1177
S1179
S1247
S1311
S1317
S1320
S1323
S1481
S1584
S1614
S1620
S1738
S1739
S1740
S1741
S1744
S1763
S1764
S1765
S1766
S1771
S1775
T1776
S1883
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation CCRCC S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation COAD S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation GBM S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation HNSCC S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation LSCC S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation LUAD S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation OV S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation PDAC S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation UCEC S629 S973 S1119 S1126 T1163 S1177 S1179 S1247 S1311 S1317 S1320 S1323 S1481 S1584 S1614 S1620 S1738 S1739 S1740 S1741 S1744 S1763 S1764 S1765 S1766 S1771 S1775 T1776 S1883 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S629
S973
S1119
S1126
T1163
S1177
S1179
S1247
S1311
S1317
S1320
S1323
S1481
S1584
S1614
S1620
S1738
S1739
S1740
S1741
S1744
S1763
S1764
S1765
S1766
S1771
S1775
T1776
S1883
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S629
S973
S1119
S1126
T1163
S1177
S1179
S1247
S1311
S1317
S1320
S1323
S1481
S1584
S1614
S1620
S1738
S1739
S1740
S1741
S1744
S1763
S1764
S1765
S1766
S1771
S1775
T1776
S1883
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.