Basic information

Full name
hydroxysteroid 11-beta dehydrogenase 2
Ensembl
ENSG00000176387.7
Summary
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Annotation
Druggable target (Tier T4)

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.2e-3--6e-29---9.5e-61.3e-40.15-0.22-
protein-1e-60--1.9e-29-1e-27--0.24-1.6e-18-9.2e-4-4.8e-5-0.18-1.7e-8

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1234567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1516171819202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HSD11B2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_PEROXISOME5.6e-50.64-0.825.3e-30.150.110.361.5e-30.440.0970.89
HALLMARK_WNT_BETA_CATENIN_SIGNALING1.9e-40.0660.0130.70.720.850.17-0.550.530.313.2e-5
HALLMARK_BILE_ACID_METABOLISM5.8e-40.210.45.7e-50.780.75-0.679.7e-5-0.410.140.97
EGFR mutation9.9e-4------9.9e-4---
Tumor Purity (WGS)1.4e-3--0.65-0.938.3e-4-0.980.1-0.314.5e-3
xcell: stroma score9.3e-30.0174.6e-30.960.18-0.71-0.590.38-0.320.0990.32
HALLMARK_FATTY_ACID_METABOLISM0.0110.170.553.2e-30.320.2-0.560.061-0.530.17-0.25
cibersort: Mast cell activated0.013-0.890.283.7e-3-0.7-0.95-0.660.012-0.550.480.021
HALLMARK_NOTCH_SIGNALING0.0190.0450.027-0.590.91-0.4310.410.340.0310.63
HALLMARK_ANDROGEN_RESPONSE0.0280.020.0150.690.76-0.290.420.063-0.220.099-0.62
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HSD11B2

BRCA0.430.320.19proteinmRNASCNVmethylationCCRCC0.290.010.03-0.040.05-0.04proteinmRNASCNVmethylationCOAD0.50-0.110.22proteinmRNASCNVmethylationGBM0.43-0.29-0.25-0.12-0.05-0.02proteinmRNASCNVmethylationHNSCC0.61-0.250.10-0.210.24-0.13proteinmRNASCNVmethylationLSCC0.16-0.010.12-0.160.16-0.02proteinmRNASCNVmethylationLUAD0.64-0.130.22-0.060.240.00proteinmRNASCNVmethylationOV0.630.090.19proteinmRNASCNVmethylationPDAC0.43-0.190.18-0.080.19-0.24proteinmRNASCNVmethylationUCEC0.76-0.200.04-0.20-0.01-0.20proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HSD11B2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.