Protein: ENSP00000316786
Gene: HSD11B2

LinkedOmicsKB © 2022-2023 Zhang Lab

HSD11B2:
hydroxysteroid 11-beta dehydrogenase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S219GRIVTVGSPAGDMPY18--44----------------
Y226SPAGDMPYPCLGAYG18--44----------------
T383LQPGQPGTTPPQDAA217--4463--------------
T384QPGQPGTTPPQDAAQ287--403845--------------
S396AAQDPNLSPGPSPAV2203----6775------------4516
S400PNLSPGPSPAVAR__19--54----------------
Showing 1 to 6 of 6 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S219GRIVTVGSPAGDMPY-----------
Y226SPAGDMPYPCLGAYG-----------
T383LQPGQPGTTPPQDAA-----------
T384QPGQPGTTPPQDAAQ-1.6e-12--1.6e-12--------
S396AAQDPNLSPGPSPAV-4.7e-7---4.4e-6-------0.011
S400PNLSPGPSPAVAR__-----------
Showing 1 to 6 of 6 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PATH-NP_TSLP_PATHWAYT3842.9e-4-2.9e-4--------
PROGENy: MAPKT3840.013-0.013--------
HALLMARK_P53_PATHWAYT3840.014-0.014--------
HALLMARK_KRAS_SIGNALING_UPT3840.025-0.025--------
HALLMARK_COAGULATIONT3840.034-0.034--------
HALLMARK_COMPLEMENTT3840.041-0.041--------
SBS20 (POLD1 mutation and defective DNA mismatch repair)S3960.044--0.044-------
xcell: Endothelial cellT3840.047-0.047--------
HALLMARK_TGF_BETA_SIGNALINGT3840.047-0.047--------
cibersort: Macrophage M2T3840.048-0.048--------
Showing 1 to 10 of 1548 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS219Y226T383T384S396S400proteinRNASCNVmethylationCCRCCS219Y226T383T384S396S400proteinRNASCNVmethylationCOADS219Y226T383T384S396S400proteinRNASCNVmethylationGBMS219Y226T383T384S396S400proteinRNASCNVmethylationHNSCCS219Y226T383T384S396S400proteinRNASCNVmethylationLSCCS219Y226T383T384S396S400proteinRNASCNVmethylationLUADS219Y226T383T384S396S400proteinRNASCNVmethylationOVS219Y226T383T384S396S400proteinRNASCNVmethylationPDACS219Y226T383T384S396S400proteinRNASCNVmethylationUCECS219Y226T383T384S396S400proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
IMPA1T384-1.8e-4--1.8e-4--------
ENOPH1S396-1.9e-3---0.038-------0.021
PPP1CCT384-3.8e-3--3.8e-3--------
BPNT1T384-4.1e-3--4.1e-3--------
MTM1T384-0.007--0.007--------
PNKPT384-9.8e-3--9.8e-3--------
INPP5KT384-0.011--0.011--------
PLPP1T384-0.014--0.014--------
PPM1GT384-0.023--0.023--------
SSH2S396-0.024----------0.024
Showing 1 to 10 of 1440 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.