Basic information

Full name
interleukin 6 signal transducer
Ensembl
ENSG00000134352.20
Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Annotation
Cancer driver (Oncogene) Druggable target (Tier T2) Receptor

Protein product

  • ENST00000381298.7 Primary ENSP00000370698.2 (16 phosphosites)
  • ENST00000336909.9
  • ENST00000502326.7
  • ENST00000381294.7
  • ENST00000381287.8
  • ENST00000522633.2
  • ENST00000381293.6
  • ENST00000381286.7
  • ENST00000396816.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-8.2e-44-0.63---3.8e-9-6.2e-33-3.2e-21--2.4e-5-
protein-1.7e-47-9.2e-6---5.3e-15-7.1e-35-1.7e-27-4.6e-9-0.68-4.9e-8

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1314151617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24Pan-cancer0510152025303540455055600-5-10-15-20-25-30-35-40-45-50-55-60proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of IL6ST with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM3.1e-139.3e-60.96-2.2e-3-0.796.9e-61.1e-60.18-0.83.6e-5
xcell: Hematopoietic stem cell2.5e-120.0770.13-0.673.4e-39.4e-98.2e-80.70.360.048
HALLMARK_ESTROGEN_RESPONSE_EARLY1.3e-112.2e-163.4e-3-0.93-0.663.4e-31.3e-31.1e-3-0.160.13
xcell: stroma score2.5e-110.0110.34-0.821.9e-32.2e-160.130.590.680.012
HALLMARK_HEME_METABOLISM8.4e-90.0120.63-0.0120.629.6e-61.2e-40.250.170.62
xcell: Cancer associated fibroblast5.5e-83.1e-30.33-0.950.0312.3e-60.0950.560.67.6e-3
HALLMARK_UV_RESPONSE_DN1.5e-70.0510.15--0.310.157.4e-110.710.240.10.026
xcell: Endothelial cell2.4e-70.320.3-0.855.1e-49.6e-16-0.320.0190.55-0.88
PROGENy: Androgen3.8e-79.5e-30.51-2.6e-3-0.17.8e-59.4e-30.22-0.872.8e-3
xcell: microenvironment score9.3e-7-0.280.15--0.523.5e-32.2e-160.980.270.550.03
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of IL6ST

BRCA0.820.450.43proteinmRNASCNVmethylationCCRCC0.42-0.080.160.040.16-0.10proteinmRNASCNVmethylationCOAD0.10proteinmRNASCNVmethylationGBM0.32-0.130.12-0.000.06-0.20proteinmRNASCNVmethylationHNSCC0.49-0.180.40-0.100.58-0.14proteinmRNASCNVmethylationLSCC0.73-0.170.49-0.190.58-0.21proteinmRNASCNVmethylationLUAD0.60-0.080.54-0.120.58-0.01proteinmRNASCNVmethylationOV0.440.250.35proteinmRNASCNVmethylationPDAC0.30-0.200.010.040.050.01proteinmRNASCNVmethylationUCEC0.54-0.150.01-0.100.03-0.22proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of IL6ST and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.