Basic information
- Full name
- KN motif and ankyrin repeat domains 2
- Ensembl
- ENSG00000197256.10
- Summary
- This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
Protein product
- ENST00000586659.5 Primary ENSP00000465650.1 (58 phosphosites)
- ENST00000589359.5
- ENST00000589894.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -4.4e-33 | - | 6.8e-7 | - | - | -1.4e-8 | -2.2e-34 | -8.4e-35 | - | -0.12 | - |
protein | -2.4e-66 | - | 0.025 | -2.3e-29 | - | -8.1e-25 | -2.3e-35 | -9.3e-35 | -8e-10 | 1.6e-8 | -3.0e-5 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of KANK2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: stroma score | 1.3e-124 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 0.002 | 3.3e-13 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 4.6e-13 | 2.2e-16 | |
HALLMARK_MYOGENESIS | 5.9e-102 | 2.2e-16 | 2.2e-16 | 4e-8 | 1.2e-3 | 5.6e-8 | 7.6e-13 | 2.2e-16 | 2.2e-16 | 5.7e-8 | 2.2e-16 | |
xcell: Cancer associated fibroblast | 1.9e-98 | 9.4e-15 | 5.1e-7 | 1.5e-14 | 0.61 | 1.2e-14 | 2.4e-21 | 2e-13 | 1.2e-8 | 1e-11 | 9.9e-18 | |
PROGENy: TGFb | 1.6e-89 | 2.2e-16 | 2.2e-16 | 4.2e-6 | 8.5e-3 | 2.2e-16 | 2.2e-16 | 7.7e-4 | 2.2e-16 | 3.3e-4 | 2.2e-16 | |
xcell: Hematopoietic stem cell | 1.7e-88 | 8.2e-23 | 2.2e-16 | 7.4e-9 | 0.16 | 5.8e-11 | 2.2e-16 | 2.2e-16 | 9.2e-5 | 7.9e-5 | 2.1e-12 | |
HALLMARK_UV_RESPONSE_DN | 1.3e-83 | 2.2e-16 | 5.7e-8 | 1.6e-4 | 1.3e-5 | 2.2e-16 | 2.2e-16 | 9e-10 | 6.9e-10 | 9.6e-3 | 2.2e-16 | |
ESTIMATE: StromalScore | 1.4e-72 | 2.2e-16 | 2.2e-5 | 3.4e-7 | 1.4e-4 | 2.2e-16 | 2.2e-16 | 2.6e-4 | 2.7e-6 | 8.4e-3 | 2.2e-16 | |
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 1.6e-58 | 2.2e-16 | 0.01 | 1.9e-5 | 1.1e-6 | 6.9e-8 | 2.2e-16 | 0.17 | 1.5e-8 | 0.026 | 2.2e-16 | |
HALLMARK_TGF_BETA_SIGNALING | 5e-47 | 2.2e-16 | 7.9e-10 | 3.9e-4 | 1.5e-4 | 0.23 | 8e-9 | 1.1e-6 | 2.8e-9 | 0.043 | 5.4e-5 | |
HALLMARK_APICAL_JUNCTION | 1.3e-46 | 8.3e-11 | 1.4e-3 | 0.026 | 2.5e-3 | 6.0e-6 | 2.1e-6 | 7.4e-5 | 2.2e-16 | 1.2e-3 | 1.2e-8 |
Cis-association
Associations between omics data of KANK2
Trans-association
Associations of the protein abundance of KANK2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.