Basic information

Full name
mitogen-activated protein kinase 9
Ensembl
ENSG00000050748.17
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

  • ENST00000452135.6 Primary ENSP00000394560.2 (3 phosphosites)
  • ENST00000455781.5
  • ENST00000343111.10
  • ENST00000393360.7
  • ENST00000347470.8
  • ENST00000425491.6
  • ENST00000539014.5
  • ENST00000397072.7
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.37-3.6e-8---0.27-6.3e-162.8e-8--1.0e-4-
protein-2.5e-20-1.6e-21-2.2e-15--8.5e-6-9.9e-33-1.3e-13--0.0150.14

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MAPK9 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_PKACA/PRKACA2.6e-11-0.950.0570.0680.411.1e-53.6e-57.8e-60.290.580.047
xcell: microenvironment score2.8e-10-0.62-0.80.310.337.0e-52.2e-160.24-0.710.0521.6e-4
cibersort: Macrophage M23.3e-80.110.490.230.0070.0518.9e-40.270.410.0460.039
xcell: Monocyte6.5e-7-0.220.0730.0220.512.5e-62.5e-7-0.9-0.970.012-1
ESTIMATE: StromalScore6.7e-70.069-0.520.830.64.3e-65.8e-8-0.96-0.280.453.5e-5
ESTIMATE: ESTIMATEScore6.9e-7-0.730.280.550.344.7e-65.5e-100.78-0.270.419.5e-3
HALLMARK_KRAS_SIGNALING_UP1.4e-6-0.71-0.940.450.591.6e-51.4e-80.760.620.817.1e-4
xcell: Macrophage M22.3e-60.080.20.40.273.5e-48.9e-110.65-0.930.9-0.56
xcell: immune score2.5e-6-0.0460.0180.140.257.7e-51e-80.29-0.760.072-0.73
HALLMARK_BILE_ACID_METABOLISM2.6e-61.3e-40.370.340.17-0.541.4e-50.050.24-0.250.036
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MAPK9

BRCA0.680.280.55proteinmRNASCNVmethylationCCRCC0.65-0.140.44-0.060.63-0.13proteinmRNASCNVmethylationCOAD0.270.070.36proteinmRNASCNVmethylationGBM0.44-0.090.03-0.030.32-0.10proteinmRNASCNVmethylationHNSCC0.55-0.230.44-0.280.67-0.18proteinmRNASCNVmethylationLSCC0.56-0.050.65-0.160.67-0.13proteinmRNASCNVmethylationLUAD0.510.120.440.060.730.10proteinmRNASCNVmethylationOV0.590.460.65proteinmRNASCNVmethylationPDAC0.190.090.15-0.260.300.03proteinmRNASCNVmethylationUCEC0.52-0.160.24-0.080.19-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MAPK9 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.