Protein: ENSP00000394560
Gene: MAPK9

LinkedOmicsKB © 2022-2023 Zhang Lab

MAPK9:
mitogen-activated protein kinase 9

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T183ACTNFMMTPYVVTRY925922-241611782---5513122245229-
Y185TNFMMTPYVVTRYYR101004104-675311799-8352938591855811947418
T188MMTPYVVTRYYRAPE15----------------32--
Showing 1 to 3 of 3 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T183ACTNFMMTPYVVTRY0.88-0.88--------
Y185TNFMMTPYVVTRYYR-1.1e-20--0.55---8.3e-9-2e-20-9.4e-140.56--0.73
T188MMTPYVVTRYYRAPE-----------
Showing 1 to 3 of 3 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PATH-NP_EGFR1_PATHWAYY1856.7e-100.230.320.146.1e-38.5e-58.6e-32.5e-5--0.8
HALLMARK_MYOGENESISY1854.6e-90.0380.170.271.7e-30.0094.3e-30.010.21-0.55
HALLMARK_TGF_BETA_SIGNALINGY1855.3e-90.230.220.334.7e-34.1e-43.2e-30.020.12-0.35
HALLMARK_UV_RESPONSE_DNY1851.1e-70.0410.980.110.0270.130.0340.0110.047-0.057
HALLMARK_COAGULATIONY1852.1e-70.15-0.790.580.0687.8e-30.0020.160.011-0.021
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONY1852.3e-70.280.090.340.0730.0390.0570.110.015-0.043
ESTIMATE: StromalScoreY1852.9e-70.290.170.90.20.0275.8e-30.0120.014-0.11
KINASE-PSP_PKCA/PRKCAY1853.6e-7-0.26--0.580.0134.5e-46.7e-59.3e-60.23-0.64
PROGENy: TGFbY1857.5e-70.180.0950.340.0570.0040.020.180.031-0.76
HALLMARK_ANGIOGENESISY1852.0e-60.0360.910.0310.10.55.2e-30.220.073-0.081
Showing 1 to 10 of 774 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT183Y185T188proteinRNASCNVmethylationCCRCCT183Y185T188proteinRNASCNVmethylationCOADT183Y185T188proteinRNASCNVmethylationGBMT183Y185T188proteinRNASCNVmethylationHNSCCT183Y185T188proteinRNASCNVmethylationLSCCT183Y185T188proteinRNASCNVmethylationLUADT183Y185T188proteinRNASCNVmethylationOVT183Y185T188proteinRNASCNVmethylationPDACT183Y185T188proteinRNASCNVmethylationUCECT183Y185T188proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ILKY1855.5e-80.360.64-0.990.030.0170.0037.4e-50.094-0.074
FERY1857.9e-80.0180.23-0.0160.170.0482.2e-30.12-0.21
NRBP2Y1855.7e-70.0310.64-0.0131.7e-30.140.330.44-8.1e-3
PRKG1Y1851.0e-60.0320.67-0.860.630.0140.0034.7e-30.031-0.17
MYLKY1851.3e-60.40.029-0.360.320.167.8e-42.3e-30.075-0.068
MAPK9Y1851.5e-69.5e-85.2e-30.840.640.117.6e-30.22-0.15-0.11
HIPK2T1832.5e-6---2.5e-6------
GRK5T1833.3e-60.810.003-2.8e-6---0.49--1.4e-3
CDK14Y1856.0e-60.744.6e-4-0.034-0.560.210.0530.067-0.016
MAP3K8Y1859.4e-60.050.98--0.0650.0480.0170.92-6.0e-4
Showing 1 to 10 of 1614 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPM1GY185-5.6e-9-2.8e-40.760.4-0.017-7.1e-3-0.06-4.3e-4-0.074--6.5e-3
ILKAPY185-1.2e-6-0.410.960.84-3.1e-5-0.011-0.22-0.35-0.75--1.3e-6
TIMM50Y185-4.3e-5-0.0230.98-0.25-0.089-0.026-0.077-0.32-0.38--0.19
PTPN2Y185-1.1e-4-3.2e-3-0.29-0.21-0.22-9.9e-3-4.1e-3-0.590.39-1
SSU72Y185-1.2e-40.930.410.14-8.4e-3-0.27-6.4e-3-0.023-0.039--1.7e-3
EYA3Y185-2.2e-4-0.43-0.045--2.4e-40.16-0.021-0.054-0.71--0.44
DUSP11Y185-3.0e-4-2.6e-30.81--0.012-0.084-0.21-0.260.98--0.39
CTDSPL2Y185-4.6e-4-0.051-0.43-0.47-8.3e-3-0.032-0.35-0.410.32--0.14
RNGTTY185-1.2e-3-0.038-0.56-0.95-0.013-0.11-0.180.420.87--0.012
IMPA2Y185-1.4e-3-6.9e-3-0.93-3.7e-30.57-0.93-0.26-0.46-0.23--0.19
Showing 1 to 10 of 720 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.