Protein: ENSP00000496964
Gene: MCM4

LinkedOmicsKB © 2022-2023 Zhang Lab

MCM4:
minichromosome maintenance complex component 4

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S3_____MSSPASTPSR154--------------4410----
T19GSRRGRATPAQTPRS985191---10882-693993837971831821107618
T23GRATPAQTPRSEDAR729266---151218-199--436716--4716
S26TPAQTPRSEDARSSP83409-17164032--51281512--4710155385
S31PRSEDARSSPSQRRR7412--88--56-1251056498--71302313
S32RSEDARSSPSQRRRG1048930-1110283266-5432201213820-84362211
S105RVEGTPRSGVRGTPV614715---10845---98--284--911
T110PRSGVRGTPVRQRPD101245104-4036889199-1025999838164761772298718
S120RQRPDLGSAQKGLQV101218113-7654808190-8045108895547541492388418
S131GLQVDLQSDGAAAED10828104-36266381-108628978645817327114411
Showing 1 to 10 of 16 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S3_____MSSPASTPSR-0.18--------0.18--
T19GSRRGRATPAQTPRS2.3e-33----3e-84.9e-288.6e-201.0e-6-0.160.7
T23GRATPAQTPRSEDAR6.8e-7-------8.5e-7-0.035
S26TPAQTPRSEDARSSP1.7e-12--1.7e-8-1.1e-5--0.028--
S31PRSEDARSSPSQRRR1e-16-----1.2e-25--4.8e-40.67
S32RSEDARSSPSQRRRG5.3e-10--0.047-5.7e-51.8e-5--4.3e-7-0.14
S105RVEGTPRSGVRGTPV-----------
T110PRSGVRGTPVRQRPD4.7e-86-9.3e-61.5e-15-3e-142.5e-304.8e-235.9e-98.4e-100.021
S120RQRPDLGSAQKGLQV3e-75-1.9e-132.3e-10-7.3e-101e-311.1e-161.7e-31.5e-100.012
S131GLQVDLQSDGAAAED3.6e-31-5.6e-6--2.1e-81.8e-263.1e-14-0.5-0.54
Showing 1 to 10 of 16 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationCCRCCS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationCOADS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationGBMS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationHNSCCS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationLSCCS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationLUADS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationOVS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationPDACS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylationUCECS3T19T23S26S31S32S105T110S120S131S142S145S326S406T514S515proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.