Basic information

Full name
myosin light chain kinase
Ensembl
ENSG00000065534.18
Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4) Protein Kinase Receptor

Protein product

  • ENST00000360304.7 Primary ENSP00000353452.3 (71 phosphosites)
  • ENST00000475616.5
  • ENST00000360772.7
  • ENST00000359169.5
  • ENST00000354792.9
  • ENST00000346322.9
  • ENST00000418370.6
  • ENST00000583087.5
  • ENST00000578202.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-8.7e-25--3.4e-8--0.045-1.1e-27-4.4e-30-4.6e-3-
protein-6.4e-76--3.5e-17-1.2e-28--7.9e-21-5.2e-35-4.7e-32-4.6e-64.1e-8-0.97

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC78910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23242526272829303132log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MYLK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESIS1.5e-1022.2e-162.2e-165e-87e-81.6e-32.7e-142.2e-162.2e-169.2e-82.2e-16
PROGENy: TGFb2.3e-912.2e-162.2e-163.7e-53.1e-105.2e-72.2e-165.2e-52.2e-163.5e-42.2e-16
xcell: stroma score4.3e-891e-94e-82.2e-163.7e-35.6e-52.2e-162.2e-161.1e-73.6e-112.2e-16
ESTIMATE: StromalScore5e-882.2e-161e-72.0e-52.2e-165.8e-72.2e-166.1e-62.2e-160.0062.2e-16
xcell: Cancer associated fibroblast7.1e-802e-97.4e-121.7e-110.914.5e-61e-261.2e-145.2e-61.4e-96.2e-11
HALLMARK_UV_RESPONSE_DN6.8e-792.2e-166.9e-67.7e-43.3e-64.7e-82.2e-161.1e-92.2e-160.012.2e-16
xcell: Hematopoietic stem cell9.8e-652.4e-124.8e-99.4e-80.124.9e-42.2e-162.2e-161.7e-61.8e-37.7e-10
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION3.1e-642.2e-164.5e-52.6e-47.4e-64.7e-52.2e-160.032.2e-160.0272.2e-16
HALLMARK_APICAL_JUNCTION1.4e-512.2e-166.7e-70.0262.0e-50.0138.6e-78.7e-52.2e-163.3e-31.8e-8
HALLMARK_TGF_BETA_SIGNALING1.9e-432.2e-165.5e-61.8e-31.3e-40.371e-93.6e-62.2e-100.022.2e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MYLK

BRCA0.71-0.15-0.09proteinmRNASCNVmethylationCCRCC0.77-0.200.18-0.160.250.07proteinmRNASCNVmethylationCOAD0.760.04-0.04proteinmRNASCNVmethylationGBM0.87-0.15-0.02-0.220.060.03proteinmRNASCNVmethylationHNSCC0.580.060.11-0.080.31-0.08proteinmRNASCNVmethylationLSCC0.850.050.08-0.030.14-0.35proteinmRNASCNVmethylationLUAD0.660.10-0.14-0.06-0.07-0.03proteinmRNASCNVmethylationOV0.790.230.21proteinmRNASCNVmethylationPDAC0.680.110.05-0.020.16-0.13proteinmRNASCNVmethylationUCEC0.89-0.120.02-0.100.11-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MYLK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.