MYLK: myosin light chain kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2cqv chain A
2yr3 chain A
5jqa chain B
5jth chain B
6c6m chain A
6c6m chain B
6c6m chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S10 DVKLVASS HISKTSL 1 8 - - - - - - - - - - - - 4 4 - - - - - - S16 SSHISKTS LSVDPSR 5 199 7 - - - - - - - - - 75 68 19 15 8 1 - - 6 - S18 HISKTSLS VDPSRVD 3 160 - - 4 4 - - - - - - 44 41 35 32 - - - - - - S255 LSIQGLDS ANRSFVR 2 73 13 - - - - - - - - - - - 31 29 - - - - - - S259 GLDSANRS FVRETKA 4 89 8 - - - - - 9 - - - 25 23 12 12 - - - - - - S269 RETKATNS DVRKEVT 2 75 - - - - - - 9 - - - 34 32 - - - - - - - - S280 KEVTNVIS KESKLDS 1 41 - - - - - - - - - - - - 21 20 - - - - - - S287 SKESKLDS LEAAAKS 3 255 17 - - - - - - - - - 35 32 89 82 - - - - - - S294 SLEAAAKS KNCSSPQ 1 8 - - - - - - - - - - - - 4 4 - - - - - - S298 AAKSKNCS SPQRGGS 4 150 23 - 4 4 - - - - - - 35 33 27 24 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S10 DVKLVASS HISKTSL - - - - - - - - - - - S16 SSHISKTS LSVDPSR -3.1e-13 - - - - - -3.1e-13 - - - - S18 HISKTSLS VDPSRVD -3e-22 - - - - - -2.3e-13 -1.7e-10 - - - S255 LSIQGLDS ANRSFVR -5.3e-3 - - - - - - -5.3e-3 - - - S259 GLDSANRS FVRETKA -7.8e-8 - - - - - -7.8e-8 - - - - S269 RETKATNS DVRKEVT -2.2e-10 - - - - - -2.2e-10 - - - - S280 KEVTNVIS KESKLDS -2.6e-8 - - - - - - -2.6e-8 - - - S287 SKESKLDS LEAAAKS -1.3e-36 - - - - - -1e-16 -1e-21 - - - S294 SLEAAAKS KNCSSPQ - - - - - - - - - - - S298 AAKSKNCS SPQRGGS -4.3e-4 - - - - - -0.01 -0.016 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S10
S16
S18
S255
S259
S269
S280
S287
S294
S298
S299
S305
S312
S324
S328
T335
S342
S343
S344
S365
S391
S422
Y471
S609
Y611
S827
S848
T883
S911
S939
S947
T965
T978
S997
S998
S999
S1015
S1020
S1063
S1091
S1093
S1122
S1123
S1151
S1208
S1209
T1221
T1230
T1337
S1386
S1388
S1419
T1423
S1438
S1570
S1617
S1759
S1760
S1765
S1768
S1772
S1773
T1774
S1776
T1778
S1779
S1788
S1793
Y1835
S1848
S1852
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation CCRCC S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation COAD S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation GBM S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation HNSCC S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation LSCC S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation LUAD S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation OV S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation PDAC S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation UCEC S10 S16 S18 S255 S259 S269 S280 S287 S294 S298 S299 S305 S312 S324 S328 T335 S342 S343 S344 S365 S391 S422 Y471 S609 Y611 S827 S848 T883 S911 S939 S947 T965 T978 S997 S998 S999 S1015 S1020 S1063 S1091 S1093 S1122 S1123 S1151 S1208 S1209 T1221 T1230 T1337 S1386 S1388 S1419 T1423 S1438 S1570 S1617 S1759 S1760 S1765 S1768 S1772 S1773 T1774 S1776 T1778 S1779 S1788 S1793 Y1835 S1848 S1852 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S10
S16
S18
S255
S259
S269
S280
S287
S294
S298
S299
S305
S312
S324
S328
T335
S342
S343
S344
S365
S391
S422
Y471
S609
Y611
S827
S848
T883
S911
S939
S947
T965
T978
S997
S998
S999
S1015
S1020
S1063
S1091
S1093
S1122
S1123
S1151
S1208
S1209
T1221
T1230
T1337
S1386
S1388
S1419
T1423
S1438
S1570
S1617
S1759
S1760
S1765
S1768
S1772
S1773
T1774
S1776
T1778
S1779
S1788
S1793
Y1835
S1848
S1852
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S10
S16
S18
S255
S259
S269
S280
S287
S294
S298
S299
S305
S312
S324
S328
T335
S342
S343
S344
S365
S391
S422
Y471
S609
Y611
S827
S848
T883
S911
S939
S947
T965
T978
S997
S998
S999
S1015
S1020
S1063
S1091
S1093
S1122
S1123
S1151
S1208
S1209
T1221
T1230
T1337
S1386
S1388
S1419
T1423
S1438
S1570
S1617
S1759
S1760
S1765
S1768
S1772
S1773
T1774
S1776
T1778
S1779
S1788
S1793
Y1835
S1848
S1852
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.