Gene: PDE9A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
phosphodiesterase 9A
Ensembl
ENSG00000160191.18
Summary
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4)

Protein product

  • ENST00000291539.11 Primary ENSP00000291539.6 (1 phosphosite)
  • ENST00000398224.3
  • ENST00000349112.7
  • ENST00000398229.7
  • ENST00000398227.7
  • ENST00000328862.10
  • ENST00000398225.7
  • ENST00000380328.6
  • ENST00000335512.8
  • ENST00000398232.7
  • ENST00000398236.7
  • ENST00000398234.7
  • ENST00000335440.10
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.025--0.021---1.9e-5-1.8e-36.5e-8--0.47-
protein0.049-8.6e-12-----5.3e-5---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC3456789101112log2(RSEM+1)tumornormal
Protein expression
CCRCCGBMLUADUCEC15.51616.51717.51818.51919.52020.52121.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PDE9A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)1.1e-3-2.5e-3-1.9e-3--0.15---0.3
xcell: T cell CD4+ central memory0.026-0.2--0.96--0.013--0.47
PROGENy: VEGF0.034-5.7e-3-0.39---0.92--0.48
xcell: T cell CD4+ naive0.037-0.24-0.37--0.21--0.4
cibersort: Mast cell activated0.043-0.48-0.057--7.1e-3---0.21
Clinical: Tumor_necrosis0.046-0.86----7.9e-3---
xcell: T cell CD4+ Th10.056-0.011-9.4e-3---0.34---0.72
Tumor Purity (ABSOLUTE)0.062-0.04-0.016--0.83---0.34
cibersort: T cell CD4+ naive0.078---0.078------
PERT-P100-PRM_VORINOSTAT0.078---0.078------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PDE9A

BRCA0.24proteinmRNASCNVmethylationCCRCC0.50-0.320.24-0.520.09-0.02proteinmRNASCNVmethylationCOAD0.07proteinmRNASCNVmethylationGBM0.40-0.130.15-0.010.160.01proteinmRNASCNVmethylationHNSCC-0.190.080.17proteinmRNASCNVmethylationLSCC-0.080.030.04proteinmRNASCNVmethylationLUAD0.53-0.060.14-0.210.210.08proteinmRNASCNVmethylationOV0.33proteinmRNASCNVmethylationPDAC-0.010.240.04proteinmRNASCNVmethylationUCEC0.61-0.270.19-0.08-0.120.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PDE9A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.