Basic information

Full name
pleckstrin homology and RUN domain containing M2
Ensembl
ENSG00000116786.13
Summary
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.2e-3-6.4e-20---0.62-4.2e-7-8.1e-8--1.0e-4-
protein-6.8e-4-5.7e-14---0.098-9.3e-18-2.1e-13-0.0387.4e-9-8.5e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012140-2-4-6-8-10-12-14Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PLEKHM2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: StromalScore5.1e-364.7e-80.029-0.0631.3e-63.6e-82.1e-54.0e-51.2e-66.1e-6
ESTIMATE: ESTIMATEScore1.2e-322.1e-60.022-0.0417e-74.8e-81.2e-61.3e-33.0e-57.7e-5
HALLMARK_KRAS_SIGNALING_UP3.3e-288.1e-50.11-0.0194.3e-52.9e-91.5e-55.0e-49.9e-70.015
xcell: microenvironment score2e-240.0110.032-8.4e-39.0e-62.4e-66.7e-70.0394.1e-32.6e-5
HALLMARK_COAGULATION5.9e-234.2e-40.23-0.0214.9e-54.9e-93.6e-62.2e-40.163.8e-3
HALLMARK_COMPLEMENT4e-220.0050.035-0.0352.7e-68.9e-94.8e-50.0293.7e-30.016
ESTIMATE: ImmuneScore3.5e-208.1e-30.098-0.0349.8e-61.6e-62.7e-60.0352.7e-30.03
KINASE-PSP_PKACA/PRKACA6.6e-205.8e-50.32-0.396.9e-52.9e-51.1e-44.3e-43.4e-40.017
xcell: Macrophage8.9e-200.0230.03-3.9e-31.4e-69.9e-72.5e-50.077.9e-30.11
HALLMARK_IL2_STAT5_SIGNALING7e-190.0120.04-0.0779.3e-41.2e-61.1e-42.7e-30.0135.7e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PLEKHM2

BRCA0.360.330.31proteinmRNASCNVmethylationCCRCC0.370.040.20-0.180.28-0.04proteinmRNASCNVmethylationCOAD0.24proteinmRNASCNVmethylationGBM0.33-0.150.21-0.100.19-0.15proteinmRNASCNVmethylationHNSCC0.64-0.210.36-0.280.45-0.40proteinmRNASCNVmethylationLSCC0.36-0.290.46-0.170.38-0.26proteinmRNASCNVmethylationLUAD0.46-0.160.38-0.210.450.00proteinmRNASCNVmethylationOV0.440.530.65proteinmRNASCNVmethylationPDAC0.22-0.050.20-0.370.34-0.20proteinmRNASCNVmethylationUCEC0.24-0.240.21-0.060.21-0.22proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PLEKHM2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.