PLEKHM2: pleckstrin homology and RUN domain containing M2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3cxb chain B
3hw2 chain B
3zfw chain X
3zfw chain Y
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S250 DTVSGPRS TASDLTS 7 262 8 - - - - - 18 - 46 28 23 21 18 15 - - 12 6 49 18 T251 TVSGPRST ASDLTSS 2 16 - - - - - - - - - - 5 4 4 3 - - - - - - S253 SGPRSTAS DLTSSKA 9 657 23 - 22 19 7 2 18 - 17 11 93 85 84 77 - - 82 33 66 18 S257 STASDLTS SKASTRS 2 17 - - - - - - - - 6 3 - - - - - - - - 6 2 S258 TASDLTSS KASTRSP 5 134 - - - - - - 53 - 5 4 25 24 - - - - 5 1 6 11 S261 DLTSSKAS TRSPTQR 4 105 - - 4 4 - - 17 - - - 5 5 38 32 - - - - - - T262 LTSSKAST RSPTQRQ 1 38 - - - - - - - - - - 20 18 - - - - - - - - S264 SSKASTRS PTQRQNP 10 1042 67 - 24 16 54 61 89 - 80 46 83 77 75 68 76 16 87 36 69 18 S281 EEPAETVS SSDTTPV 1 18 - - - - - - 18 - - - - - - - - - - - - - T286 TVSSSDTT PVHTTSQ 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S250 DTVSGPRS TASDLTS 0.26 - - - - 7.9e-4 -5.6e-3 - - - 0.17 T251 TVSGPRST ASDLTSS - - - - - - - - - - - S253 SGPRSTAS DLTSSKA 0.062 - -0.65 - - - -0.092 0.93 - 3.9e-6 0.11 S257 STASDLTS SKASTRS - - - - - - - - - - - S258 TASDLTSS KASTRSP -1.1e-10 - - - - - -1.1e-10 - - - - S261 DLTSSKAS TRSPTQR 0.002 - - - - - - 0.002 - - - T262 LTSSKAST RSPTQRQ -2.7e-9 - - - - - -2.7e-9 - - - - S264 SSKASTRS PTQRQNP 0.87 - 0.49 7.3e-5 - -8.7e-5 -6.4e-8 -0.46 0.098 7.5e-9 -0.012 S281 EEPAETVS SSDTTPV - - - - - - - - - - - T286 TVSSSDTT PVHTTSQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S250
T251
S253
S257
S258
S261
T262
S264
S281
T286
S327
S329
S334
S341
S353
S357
S359
S364
T367
S371
S411
T439
S441
S459
S532
S540
T546
S559
S563
S564
S568
S766
S922
S925
T926
S1014
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation CCRCC S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation COAD S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation GBM S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation HNSCC S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation LSCC S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation LUAD S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation OV S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation PDAC S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation UCEC S250 T251 S253 S257 S258 S261 T262 S264 S281 T286 S327 S329 S334 S341 S353 S357 S359 S364 T367 S371 S411 T439 S441 S459 S532 S540 T546 S559 S563 S564 S568 S766 S922 S925 T926 S1014 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S250
T251
S253
S257
S258
S261
T262
S264
S281
T286
S327
S329
S334
S341
S353
S357
S359
S364
T367
S371
S411
T439
S441
S459
S532
S540
T546
S559
S563
S564
S568
S766
S922
S925
T926
S1014
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S250
T251
S253
S257
S258
S261
T262
S264
S281
T286
S327
S329
S334
S341
S353
S357
S359
S364
T367
S371
S411
T439
S441
S459
S532
S540
T546
S559
S563
S564
S568
S766
S922
S925
T926
S1014
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.