Gene: PPP1R12A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
protein phosphatase 1 regulatory subunit 12A
Ensembl
ENSG00000058272.19
Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.29-3.2e-11--1.2e-4-9.7e-4-1.6e-19-7.6e-4-
protein-4.9e-16-0.1-1.2e-24-2.7e-3-4.4e-24-5.5e-20-4.4e-33.4e-14-5.3e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.51313.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.529log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPP1R12A with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: stroma score1e-543.3e-52.2e-161.5e-85.4e-40.284.1e-66.3e-98.6e-35.1e-82.2e-16
ESTIMATE: StromalScore7.9e-542.2e-163.6e-67.3e-62.0e-60.0387.2e-51.7e-75.5e-41.3e-42.2e-16
PROGENy: TGFb1.5e-532.2e-162.2e-162.8e-41.1e-30.0351.3e-32.7e-43.5e-31.2e-72.2e-16
xcell: Cancer associated fibroblast2.5e-422.0e-53.3e-81.3e-80.860.148.7e-75e-92.6e-35e-76.9e-13
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION3.9e-422.2e-161.5e-35.2e-46.7e-70.531.6e-35.0e-43.2e-31.7e-62.2e-16
HALLMARK_MYOGENESIS1.7e-411.7e-72.7e-82.5e-58.4e-40.881.2e-31.7e-51.3e-32e-72.2e-16
HALLMARK_UV_RESPONSE_DN8.5e-411.1e-64.8e-90.0142.5e-80.013.9e-42.2e-70.120.0122.2e-16
HALLMARK_APICAL_JUNCTION8.6e-335.9e-72.3e-40.0752.9e-50.826.6e-42.6e-50.0144.9e-62.2e-16
xcell: Hematopoietic stem cell1.7e-253.3e-62.2e-161.3e-40.3-0.290.0183.0e-40.0140.232.3e-11
ESTIMATE: ESTIMATEScore2e-254.0e-40.156.8e-54.7e-60.0132.2e-35.9e-69.5e-40.192.2e-6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPP1R12A

BRCA0.500.390.27proteinmRNASCNVmethylationCCRCC0.640.110.020.15-0.05-0.19proteinmRNASCNVmethylationCOAD0.490.230.38proteinmRNASCNVmethylationGBM0.35-0.100.20-0.210.23-0.11proteinmRNASCNVmethylationHNSCC0.60-0.270.19-0.220.39-0.09proteinmRNASCNVmethylationLSCC0.54-0.120.36-0.070.51-0.14proteinmRNASCNVmethylationLUAD0.62-0.160.33-0.160.56-0.01proteinmRNASCNVmethylationOV0.430.410.51proteinmRNASCNVmethylationPDAC0.520.090.160.090.44-0.10proteinmRNASCNVmethylationUCEC0.78-0.010.07-0.060.14-0.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPP1R12A and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.