Basic information

Full name
protein phosphatase 2 regulatory subunit B'gamma
Ensembl
ENSG00000078304.19
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000334743.9 Primary ENSP00000333905.4 (2 phosphosites)
  • ENST00000556260.6
  • ENST00000422945.6
  • ENST00000328724.9
  • ENST00000350249.7
  • ENST00000445439.7
  • ENST00000557095.5
  • ENST00000554442.5
  • ENST00000556946.1
  • ENST00000557714.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-7.1e-4--0.031---0.37-1.8e-4-0.62--0.78-
protein0.94--3.0e-4-0.025--0.720.140.17-1.2e-32.1e-13-0.59

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC20.52121.52222.52323.52424.52525.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPP2R5C with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)1.4e-6-0.52-1.4e-48.0e-40.280.5-0.0480.22
KINASE-PSP_CDK51.4e-3---2.8e-50.067-0.26--0.120.46
HALLMARK_SPERMATOGENESIS0.0030.92-0.920.139.2e-90.120.084-0.25-0.640.11-0.23
BMPR2 mutation5.8e-3--5.8e-3-------
CTNNB1 mutation6.4e-3--0.63------7.4e-4
SBS3 (HRD)9.2e-3-------9.2e-3--
Tumor Purity (ABSOLUTE)0.025-0.77-0.640.473.9e-33.4e-50.550.33-0.180.84-0.74
Clinical: BMI0.027-0.42-0.33-0.13-0.520.008-0.110.046
ZNF540 mutation0.028--0.028-------
PERT-PSP_INSULIN0.04---0.890.044----0.16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPP2R5C

BRCA0.260.280.55proteinmRNASCNVmethylationCCRCC0.57-0.090.53-0.090.75-0.20proteinmRNASCNVmethylationCOAD0.260.270.58proteinmRNASCNVmethylationGBM0.560.030.35-0.010.57-0.03proteinmRNASCNVmethylationHNSCC0.510.070.570.110.670.09proteinmRNASCNVmethylationLSCC0.560.070.470.040.730.04proteinmRNASCNVmethylationLUAD0.65-0.010.310.080.57-0.04proteinmRNASCNVmethylationOV0.020.200.62proteinmRNASCNVmethylationPDAC0.250.130.070.080.590.03proteinmRNASCNVmethylationUCEC0.31-0.050.140.170.100.18proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPP2R5C and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.