Gene: PRKCH

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
protein kinase C eta
Ensembl
ENSG00000027075.15
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-9.9e-28-3.4e-25---6.5e-11-9.5e-25-4.8e-32--5.6e-5-
protein-8.4e-24-4.8e-18---1.1e-5-8.1e-33-9.4e-33-1.1e-5-0.32-0.24

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC171819202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer0510152025303540455055600-5-10-15-20-25-30-35-40-45-50-55-60proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PRKCH with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: microenvironment score2.4e-431.7e-76.5e-6-6.4e-55.9e-102.2e-165.1e-83.7e-50.160.022
ESTIMATE: ImmuneScore6.5e-411.7e-63.4e-3-6.2e-52.7e-82.2e-164.3e-86.6e-50.112.7e-4
xcell: T cell CD8+ central memory2.2e-361.5e-65.4e-3-8.7e-33.4e-116.2e-149.6e-83.5e-40.0568.7e-3
HALLMARK_ALLOGRAFT_REJECTION5.2e-361.2e-40.026-8.2e-51.0e-62.2e-162.8e-76.1e-40.018.1e-4
HALLMARK_IL2_STAT5_SIGNALING2.9e-331.0e-40.003-1.9e-42.2e-52.2e-167.7e-61.3e-50.156.2e-3
ESTIMATE: ESTIMATEScore3.4e-334.6e-51.2e-3-7.3e-54.9e-86.7e-101.7e-61.9e-50.41.3e-3
xcell: immune score3.2e-325.2e-60.52-5.8e-42.9e-82.2e-162.2e-58.8e-40.046.0e-4
PROGENy: Trail2.4e-302.1e-67.7e-4-0.0555.8e-62.2e-164.2e-46.2e-50.663.2e-4
HALLMARK_COMPLEMENT1.1e-277.4e-50.17-1.2e-32.1e-52.2e-164.8e-42.2e-30.0856.4e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING1.2e-262.5e-40.22-2.2e-32.1e-52.2e-162.8e-47.5e-30.0361.3e-3
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* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PRKCH

BRCA0.540.050.23proteinmRNASCNVmethylationCCRCC0.66-0.070.27-0.150.470.06proteinmRNASCNVmethylationCOAD0.04proteinmRNASCNVmethylationGBM0.53-0.070.06-0.31-0.180.26proteinmRNASCNVmethylationHNSCC0.470.240.170.070.56-0.06proteinmRNASCNVmethylationLSCC0.500.140.12-0.030.62-0.17proteinmRNASCNVmethylationLUAD0.630.13-0.110.090.17-0.03proteinmRNASCNVmethylationOV0.620.300.22proteinmRNASCNVmethylationPDAC0.090.06-0.07-0.180.110.07proteinmRNASCNVmethylationUCEC0.530.05-0.050.04-0.07-0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PRKCH and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.