Gene: PTK2B

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
protein tyrosine kinase 2 beta
Ensembl
ENSG00000120899.18
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T2) Protein Kinase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2e-15--2.2e-10--4.9e-5-7.9e-10-5.5e-18--0.49-
protein-0.36-0.92-3.3e-4-3.8e-12-6.7e-3-3.7e-12-0.0122.3e-40.016

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC6.577.588.599.51010.51111.51212.51313.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.52626.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PTK2B with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore2.6e-912.2e-162.2e-160.0020.0124.5e-112.2e-162.2e-165.4e-95.1e-72.2e-16
HALLMARK_ALLOGRAFT_REJECTION2.2e-852.2e-162.2e-161.3e-30.0232.2e-162.2e-161.4e-83.8e-82.4e-52.2e-16
HALLMARK_COMPLEMENT4.2e-842.2e-162.2e-161.1e-31.3e-31.9e-102.2e-161.9e-64.6e-72.6e-92.2e-16
xcell: immune score1.5e-792.2e-162.2e-169.9e-49.4e-32.2e-162.2e-161.8e-97.3e-87.8e-44.6e-10
HALLMARK_IL6_JAK_STAT3_SIGNALING4.2e-782.2e-162.2e-161.1e-30.0177.6e-92.2e-162.3e-88.2e-71.2e-52.2e-16
HALLMARK_INFLAMMATORY_RESPONSE2.4e-739.2e-102.2e-161.3e-32.3e-31.2e-82.2e-162.3e-74.5e-71.3e-52.2e-16
HALLMARK_INTERFERON_GAMMA_RESPONSE4.5e-692.2e-162.2e-163.2e-37.6e-49.3e-72.2e-164.1e-52.1e-68.1e-32.2e-16
ESTIMATE: ESTIMATEScore4.1e-577.9e-72.2e-160.0670.0131e-72.2e-162.6e-71.0e-61.3e-39.9e-10
HALLMARK_IL2_STAT5_SIGNALING1.3e-564.8e-101.1e-80.0110.0031.2e-72.2e-162.4e-94.5e-74.8e-42.6e-6
HALLMARK_INTERFERON_ALPHA_RESPONSE5e-512.2e-162.2e-161.5e-34.0e-49.4e-64.5e-92.9e-38.2e-46.5e-34.4e-7
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PTK2B

BRCA0.720.200.35proteinmRNASCNVmethylationCCRCC0.78-0.26-0.00-0.130.05-0.05proteinmRNASCNVmethylationCOAD0.440.440.37proteinmRNASCNVmethylationGBM0.78-0.180.02-0.200.020.10proteinmRNASCNVmethylationHNSCC0.760.060.40-0.010.40-0.01proteinmRNASCNVmethylationLSCC0.88-0.210.55-0.240.60-0.32proteinmRNASCNVmethylationLUAD0.86-0.280.52-0.210.56-0.16proteinmRNASCNVmethylationOV0.600.250.34proteinmRNASCNVmethylationPDAC0.65-0.140.36-0.130.47-0.07proteinmRNASCNVmethylationUCEC0.810.080.130.020.20-0.16proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PTK2B and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.