PTK2B: protein tyrosine kinase 2 beta
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2lk4 chain A
3cc6 chain A
3et7 chain A
3fzo chain A
3fzp chain A
3fzr chain A
3fzs chain A
3fzt chain A
3gm1 chain A
3gm1 chain B
3gm2 chain A
3gm3 chain A
3h3c chain A
3u3f chain A
3u3f chain B
3u3f chain C
3u3f chain D
4eku chain A
4h1j chain A
4h1m chain A
4r32 chain A
4xef chain A
4xef chain D
4xek chain A
4xev chain A
4xev chain D
5to8 chain A
5tob chain A
6lf3 chain A
6lf3 chain B
6lf3 chain C
6lf3 chain D
6lf3 chain E
6lf3 chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T15 LSRVKLGT LRRPEGP 4 60 17 - 4 4 - - 17 - - - - - - - - - 13 5 - - S361 LQGEHQGS LIIHPRK 3 78 - - - - - - 17 - - - 5 4 28 24 - - - - - - S375 KDGEKRNS LPQIPML 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S392 EARRSHLS ESCSIES 5 116 6 - - - - - 36 - 5 3 29 28 5 4 - - - - - - S394 RRSHLSES CSIESDI 5 190 15 - - - - - 18 - 34 18 24 22 32 27 - - - - - - S396 SHLSESCS IESDIYA 6 350 47 - - - - - 35 - 69 39 24 20 53 47 14 2 - - - - S399 SESCSIES DIYAEIP 5 105 16 - - - - - 17 - 5 3 19 18 15 12 - - - - - - Y579 RYIEDEDY YKASVTR 4 61 - - - - - - 9 - - - 15 14 9 8 - - - - 6 - Y580 YIEDEDYY KASVTRL 5 143 - - - - - - 35 - - - 44 43 5 4 - - 5 1 6 - S583 DEDYYKAS VTRLPIK 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T15 LSRVKLGT LRRPEGP - - - - - - - - - - - S361 LQGEHQGS LIIHPRK 1.1e-4 - - - - - - 1.1e-4 - - - S375 KDGEKRNS LPQIPML -5.8e-11 - -0.25 -5e-11 - 0.017 -7.3e-10 -2.2e-20 -7.7e-3 6.4e-8 -0.61 S392 EARRSHLS ESCSIES -7.3e-6 - - - - - -7.3e-6 - - - - S394 RRSHLSES CSIESDI -2e-11 - - - - -2.9e-3 -1.4e-8 -3.1e-3 - - - S396 SHLSESCS IESDIYA -4.1e-9 - - - - -0.46 -2.4e-5 -1.8e-7 - - - S399 SESCSIES DIYAEIP - - - - - - - - - - - Y579 RYIEDEDY YKASVTR - - - - - - - - - - - Y580 YIEDEDYY KASVTRL -2.7e-3 - - - - - -2.7e-3 - - - - S583 DEDYYKAS VTRLPIK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T15
S361
S375
S392
S394
S396
S399
Y579
Y580
S583
S746
T749
T751
S752
Y756
S758
S762
T765
S778
Y834
S839
T842
Y849
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation CCRCC T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation COAD T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation GBM T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation HNSCC T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation LSCC T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation LUAD T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation OV T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation PDAC T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation UCEC T15 S361 S375 S392 S394 S396 S399 Y579 Y580 S583 S746 T749 T751 S752 Y756 S758 S762 T765 S778 Y834 S839 T842 Y849 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T15
S361
S375
S392
S394
S396
S399
Y579
Y580
S583
S746
T749
T751
S752
Y756
S758
S762
T765
S778
Y834
S839
T842
Y849
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T15
S361
S375
S392
S394
S396
S399
Y579
Y580
S583
S746
T749
T751
S752
Y756
S758
S762
T765
S778
Y834
S839
T842
Y849
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.