Gene: RAN

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
RAN, member RAS oncogene family
Ensembl
ENSG00000132341.12
Summary
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3e-75-2.9e-16--6.7e-142.2e-338.1e-17-5.6e-7-
protein6.1e-29-1.3e-291.2e-14-5e-205.3e-189.5e-3-3.8e-6-2.3e-40.64

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1111.51212.51313.51414.51515.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC14161820222426283032log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RAN with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V22.9e-358.7e-53.5e-50.123.6e-42.1e-62.2e-161.0e-4-0.112.7e-55.8e-11
PERT-PSP_NOCODAZOLE9.4e-352.8e-81.4e-32.7e-56.7e-65.6e-53e-91.1e-30.168.2e-45.1e-4
KINASE-PSP_CDK15.5e-323.1e-61.1e-35.2e-36.9e-71.1e-62.3e-62.9e-30.11.5e-44.1e-4
HALLMARK_E2F_TARGETS2e-319.4e-53.3e-30.129.7e-31.1e-42.2e-161.2e-3-0.86.9e-73.8e-9
KINASE-PSP_CDK22.6e-311.3e-63.3e-40.0485.7e-42.6e-72.3e-50.0180.183.3e-61.9e-7
HALLMARK_G2M_CHECKPOINT1.2e-305.2e-44.8e-40.160.0345.2e-42.2e-161.9e-3-0.92.0e-68.1e-11
HALLMARK_MYC_TARGETS_V15.3e-209.2e-40.0550.290.0020.0174.3e-99.9e-4-0.264.6e-53.7e-7
KINASE-PSP_CK2A1/CSNK2A11.7e-190.180.0240.532.2e-41.1e-41.9e-31.3e-40.0241.7e-65.2e-3
HALLMARK_DNA_REPAIR2.2e-180.0610.120.160.0012.0e-53.4e-82.3e-4-0.014.8e-42.9e-7
chromosomal instability5.9e-185.2e-44.1e-4-0.790.0961.6e-42.2e-166.5e-30.730.0420.068
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RAN

BRCA0.510.360.33proteinmRNASCNVmethylationCCRCC0.340.050.160.140.33-0.09proteinmRNASCNVmethylationCOAD0.220.240.35proteinmRNASCNVmethylationGBM0.40-0.190.17-0.150.25-0.12proteinmRNASCNVmethylationHNSCC0.600.000.280.020.200.02proteinmRNASCNVmethylationLSCC0.71-0.070.51-0.140.44-0.13proteinmRNASCNVmethylationLUAD0.51-0.040.32-0.210.50-0.18proteinmRNASCNVmethylationOV-0.140.160.48proteinmRNASCNVmethylationPDAC0.45-0.050.37-0.230.60-0.16proteinmRNASCNVmethylationUCEC0.54-0.080.110.050.00-0.13proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RAN and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.