Gene: RASGRP2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
RAS guanyl releasing protein 2
Ensembl
ENSG00000068831.19
Summary
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Protein product

  • ENST00000394432.8 Primary ENSP00000377953.3 (16 phosphosites)
  • ENST00000354024.7
  • ENST00000377497.7
  • ENST00000377494.5
  • ENST00000394430.5
  • ENST00000377486.7
  • ENST00000377487.5
  • ENST00000377489.5
  • ENST00000394429.5
  • ENST00000394428.5
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.7e-22-1.2e-12---1.7e-3-6.3e-32-2.6e-31--0.023-
protein-7e-9-2.6e-6-0.01--0.52--1.1e-31-1.2e-75.7e-3-0.01

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23456789101112log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLUADOVPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer01020304050607080901001101200-10-20-30-40-50-60-70-80-90-100-110-120proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RASGRP2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_INFLAMMATORY_RESPONSE2.2e-311e-70.10.10.045e-8-1.4e-45.2e-42.2e-167.6e-4
HALLMARK_IL2_STAT5_SIGNALING2.5e-307.2e-100.0180.140.0251.9e-5-2.3e-75.0e-42.5e-83.5e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING3e-304e-80.930.330.0373.8e-11-4.3e-52.0e-42.2e-162.6e-3
HALLMARK_COMPLEMENT5.9e-296.9e-80.510.110.067e-8-2.6e-64.0e-47.1e-103.1e-5
ESTIMATE: ImmuneScore6e-291.6e-80.470.450.182.9e-8-3.3e-63.9e-42.2e-162.2e-3
ESTIMATE: ESTIMATEScore4.1e-285e-94.6e-40.450.211.2e-6-2.4e-41.7e-31.4e-62.9e-7
HALLMARK_KRAS_SIGNALING_UP1.4e-271.6e-51.7e-70.230.113.4e-6-1.8e-43.6e-43.6e-35e-8
xcell: microenvironment score1e-263.3e-92.7e-40.630.184.1e-7-8.0e-41.7e-47.8e-54.8e-6
PROGENy: NFkB3.1e-262.7e-50.280.0360.0435.9e-5-1.7e-47.3e-32.2e-161.9e-4
HALLMARK_TNFA_SIGNALING_VIA_NFKB2.3e-242.4e-40.0280.130.0345.9e-5-1.9e-66.4e-44.4e-71.3e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RASGRP2

BRCA0.540.230.15proteinmRNASCNVmethylationCCRCC0.60-0.120.10-0.110.15-0.05proteinmRNASCNVmethylationCOAD0.090.060.04proteinmRNASCNVmethylationGBM0.590.070.22-0.130.16-0.07proteinmRNASCNVmethylationHNSCC0.550.13-0.180.22-0.09-0.11proteinmRNASCNVmethylationLSCC0.06-0.020.18proteinmRNASCNVmethylationLUAD0.50-0.18-0.09-0.21-0.15-0.01proteinmRNASCNVmethylationOV0.420.180.02proteinmRNASCNVmethylationPDAC0.27-0.03-0.010.040.03-0.01proteinmRNASCNVmethylationUCEC0.63-0.07-0.15-0.25-0.00-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RASGRP2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.