Basic information

Full name
ribosomal protein L5
Ensembl
ENSG00000122406.14
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]
Annotation
Cancer driver (TSG) Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.026-5.4e-20---1e-140.6-0.48--1.2e-7-
protein2.6e-89-3.9e-247.1e-28-3.2e-84.9e-359e-342.4e-10-1.7e-77.1e-6

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC11.51212.51313.51414.51515.51616.51717.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC26.52727.52828.52929.53030.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RPL5 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V27.9e-451.2e-134e-90.0942e-72.4e-38.7e-52.2e-160.0020.0115.9e-4
HALLMARK_UNFOLDED_PROTEIN_RESPONSE3.5e-313.2e-87.7e-50.0667.3e-80.0386.7e-33.8e-130.216.2e-60.027
HALLMARK_MTORC1_SIGNALING3.8e-287.9e-91.2e-40.0841.6e-60.0791.9e-75.4e-70.0483.3e-30.081
HALLMARK_DNA_REPAIR5.5e-282.9e-49.1e-80.0885.6e-63.6e-34.0e-43.8e-52.5e-31.4e-37.4e-3
PROGENy: PI3K5.9e-282.0e-60.0535.7e-51.1e-32.2e-160.0254.8e-50.681.5e-39.7e-3
HALLMARK_E2F_TARGETS8.9e-272.2e-161.5e-51.5e-30.012-0.873.0e-41.2e-70.373.4e-40.016
HALLMARK_MYC_TARGETS_V14.3e-233.1e-72.3e-36.2e-30.0020.0561.8e-43.7e-70.0566.3e-30.056
HALLMARK_G2M_CHECKPOINT1e-212e-99.1e-50.0040.0460.742.7e-39.7e-90.532.4e-40.033
KINASE-PSP_CDK16e-202.2e-160.520.110.0020.0372.7e-43.5e-70.130.0170.52
xcell: T cell CD4+ Th24.6e-182.4e-110.0330.0241.8e-40.820.018.2e-40.0380.0090.08
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RPL5

BRCA0.210.180.44proteinmRNASCNVmethylationCCRCC0.12-0.100.120.050.230.22proteinmRNASCNVmethylationCOAD0.310.300.15proteinmRNASCNVmethylationGBM0.32-0.02-0.00-0.040.23-0.08proteinmRNASCNVmethylationHNSCC0.24-0.070.25-0.090.52-0.03proteinmRNASCNVmethylationLSCC0.31-0.230.01-0.190.26-0.16proteinmRNASCNVmethylationLUAD0.17-0.06-0.01-0.150.42-0.11proteinmRNASCNVmethylationOV0.47-0.150.02proteinmRNASCNVmethylationPDAC0.05-0.150.18-0.160.230.01proteinmRNASCNVmethylationUCEC0.250.010.03-0.080.06-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RPL5 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.