Basic information

Full name
ribosomal protein L6
Ensembl
ENSG00000089009.15
Summary
This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.2e-7-1.9e-26---3e-125.1e-185.5e-5--4.9e-7-
protein1.1e-36-1.1e-241.6e-23-4.9e-103.1e-3-0.647.1e-10-3.3e-33.2e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1212.51313.51414.51515.51616.51717.518log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC24.52525.52626.52727.52828.52929.530log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RPL6 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V21.6e-222.3e-42.8e-50.0312.8e-32.7e-30.0633.2e-45.1e-69.4e-40.13
PROGENy: PI3K1.1e-190.130.0177.2e-58.4e-48e-90.0258.1e-30.682.1e-46.6e-3
HALLMARK_UNFOLDED_PROTEIN_RESPONSE1.6e-191.5e-34.5e-50.0939.8e-60.0580.0878.8e-40.112.9e-60.046
cibersort: Neutrophil3.7e-140.0989.6e-5-0.0140.0184.9e-44.8e-72.9e-3-3.5e-44.5e-123.0e-4
HALLMARK_MTORC1_SIGNALING3.7e-140.0131.1e-30.131.6e-30.140.130.120.0475.1e-60.016
HALLMARK_DNA_REPAIR1.4e-120.0343.2e-40.0930.0230.0210.420.211.7e-32.3e-30.03
KINASE-PSP_CDK25.6e-120.0356.2e-42.5e-40.50.0730.28.3e-30.153.0e-60.9
HALLMARK_OXIDATIVE_PHOSPHORYLATION1.5e-110.047-0.720.0320.290.0313.4e-36.5e-36.8e-50.111.8e-3
HALLMARK_MYC_TARGETS_V12.6e-110.0540.030.0140.20.030.580.010.0535.5e-50.049
xcell: T cell CD4+ Th23.6e-111.4e-30.0650.0950.0660.190.160.0750.0466.4e-60.16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RPL6

BRCA0.060.060.28proteinmRNASCNVmethylationCCRCC0.260.120.36proteinmRNASCNVmethylationCOAD0.110.000.09proteinmRNASCNVmethylationGBM0.360.090.01proteinmRNASCNVmethylationHNSCC0.27-0.060.28proteinmRNASCNVmethylationLSCC0.18-0.130.45proteinmRNASCNVmethylationLUAD0.24-0.000.53proteinmRNASCNVmethylationOV0.400.020.30proteinmRNASCNVmethylationPDAC0.160.150.41proteinmRNASCNVmethylationUCEC0.23-0.080.25proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RPL6 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.