Basic information

Full name
ribosomal protein S19
Ensembl
ENSG00000105372.8
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.2e-23-3.1e-29---7.8e-61e-218.1e-13--0.28-
protein5.2e-84-4.6e-131.3e-25-5.6e-52.1e-359e-355.3e-90.470.055

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1111.51212.51313.51414.51515.51616.517log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2727.52828.52929.53030.531log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RPS19 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V23.3e-180.0093.9e-33.9e-31.4e-40.0359.6e-55.4e-30.0270.22.2e-3
HALLMARK_E2F_TARGETS5.4e-130.0310.011.5e-36.5e-50.527.8e-47.4e-30.980.0980.011
PROGENy: PI3K2.7e-123.3e-30.0161.1e-49.3e-46.8e-50.0650.0190.870.790.32
HALLMARK_UNFOLDED_PROTEIN_RESPONSE6.2e-120.11.6e-30.0343.5e-40.0260.0651.7e-40.046-0.490.034
HALLMARK_G2M_CHECKPOINT6.5e-120.0256.4e-38.6e-31.1e-40.544.1e-33.6e-3-0.770.110.01
HALLMARK_MYC_TARGETS_V11.6e-110.0980.0458.4e-37.5e-40.0161.2e-30.0140.70.0480.24
KINASE-PSP_CDK22.4e-110.240.214.2e-45.1e-40.681.2e-33.6e-4-0.860.517.1e-5
HALLMARK_DNA_REPAIR2.6e-110.846.3e-40.0541.5e-70.243.1e-30.0840.230.50.011
HALLMARK_MTORC1_SIGNALING2.9e-100.0594.2e-30.0810.0210.331.6e-56.1e-30.230.870.081
xcell: T cell CD4+ Th29.4e-90.0190.0710.138.9e-60.470.0140.0540.540.260.23
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RPS19

BRCA0.04-0.130.19proteinmRNASCNVmethylationCCRCC0.32-0.030.16-0.03-0.00-0.02proteinmRNASCNVmethylationCOAD0.09-0.070.32proteinmRNASCNVmethylationGBM0.050.19-0.17-0.080.41-0.26proteinmRNASCNVmethylationHNSCC0.23-0.070.15-0.240.42-0.15proteinmRNASCNVmethylationLSCC0.130.08-0.05-0.360.41-0.47proteinmRNASCNVmethylationLUAD0.23-0.100.25-0.300.57-0.23proteinmRNASCNVmethylationOV0.370.150.31proteinmRNASCNVmethylationPDAC-0.070.070.06-0.120.36-0.18proteinmRNASCNVmethylationUCEC0.340.04-0.03-0.210.11-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RPS19 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.