Basic information
- Full name
- ribosomal protein S19
- Ensembl
- ENSG00000105372.8
- Summary
- Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
- Annotation
- Essential genes
Protein product
- ENST00000598742.6 Primary ENSP00000470972.1 (2 phosphosites)
- ENST00000600467.6
- ENST00000593863.5
- ENST00000221975.6
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.2e-23 | - | 3.1e-29 | - | - | -7.8e-6 | 1e-21 | 8.1e-13 | - | -0.28 | - |
protein | 5.2e-84 | - | 4.6e-13 | 1.3e-25 | - | 5.6e-5 | 2.1e-35 | 9e-35 | 5.3e-9 | 0.47 | 0.055 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of RPS19 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_MYC_TARGETS_V2 | 3.3e-18 | 0.009 | 3.9e-3 | 3.9e-3 | 1.4e-4 | 0.035 | 9.6e-5 | 5.4e-3 | 0.027 | 0.2 | 2.2e-3 | |
HALLMARK_E2F_TARGETS | 5.4e-13 | 0.031 | 0.01 | 1.5e-3 | 6.5e-5 | 0.52 | 7.8e-4 | 7.4e-3 | 0.98 | 0.098 | 0.011 | |
PROGENy: PI3K | 2.7e-12 | 3.3e-3 | 0.016 | 1.1e-4 | 9.3e-4 | 6.8e-5 | 0.065 | 0.019 | 0.87 | 0.79 | 0.32 | |
HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 6.2e-12 | 0.1 | 1.6e-3 | 0.034 | 3.5e-4 | 0.026 | 0.065 | 1.7e-4 | 0.046 | -0.49 | 0.034 | |
HALLMARK_G2M_CHECKPOINT | 6.5e-12 | 0.025 | 6.4e-3 | 8.6e-3 | 1.1e-4 | 0.54 | 4.1e-3 | 3.6e-3 | -0.77 | 0.11 | 0.01 | |
HALLMARK_MYC_TARGETS_V1 | 1.6e-11 | 0.098 | 0.045 | 8.4e-3 | 7.5e-4 | 0.016 | 1.2e-3 | 0.014 | 0.7 | 0.048 | 0.24 | |
KINASE-PSP_CDK2 | 2.4e-11 | 0.24 | 0.21 | 4.2e-4 | 5.1e-4 | 0.68 | 1.2e-3 | 3.6e-4 | -0.86 | 0.51 | 7.1e-5 | |
HALLMARK_DNA_REPAIR | 2.6e-11 | 0.84 | 6.3e-4 | 0.054 | 1.5e-7 | 0.24 | 3.1e-3 | 0.084 | 0.23 | 0.5 | 0.011 | |
HALLMARK_MTORC1_SIGNALING | 2.9e-10 | 0.059 | 4.2e-3 | 0.081 | 0.021 | 0.33 | 1.6e-5 | 6.1e-3 | 0.23 | 0.87 | 0.081 | |
xcell: T cell CD4+ Th2 | 9.4e-9 | 0.019 | 0.071 | 0.13 | 8.9e-6 | 0.47 | 0.014 | 0.054 | 0.54 | 0.26 | 0.23 |
Cis-association
Associations between omics data of RPS19
Trans-association
Associations of the protein abundance of RPS19 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.