Basic information

Full name
remodeling and spacing factor 1
Ensembl
ENSG00000048649.13
Summary
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.33--0.65--0.065-0.069-0.027-0.63-
protein1e-28-0.174.3e-9-7.9e-57.5e-231.7e-221.8e-6-8.9e-3-0.14

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.51313.51414.515log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2222.52323.52424.52525.52626.52727.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RSF1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)5.2e-21-2.3e-3-4.2e-180.046.5e-69.9e-3-0.050.039
xcell: T cell CD4+ Th13e-182.5e-51.5e-30.425.9e-120.621.5e-34.3e-40.630.166.7e-4
chromosomal instability3e-147.0e-6-0.0230.662.5e-51.9e-31.3e-61.3e-60.0150.120.7
Tumor Purity (ABSOLUTE)2.2e-130.16.1e-3-0.561.1e-108.1e-33.7e-60.130.450.210.034
HALLMARK_E2F_TARGETS1.4e-121.5e-4-0.20.821.3e-60.0986.4e-60.010.0690.212.5e-3
HALLMARK_SPERMATOGENESIS2.6e-120.0260.780.979.4e-81.8e-33.6e-71.2e-30.0360.770.67
HALLMARK_G2M_CHECKPOINT5.5e-128.9e-4-0.290.993.2e-60.0272.9e-64.1e-30.380.291.6e-3
HALLMARK_MITOTIC_SPINDLE1.5e-80.0140.48-0.771.5e-30.190.0650.036-0.630.0162.9e-6
HALLMARK_DNA_REPAIR2.5e-71.1e-4-0.37-0.70.0210.693.4e-70.0250.180.230.26
HALLMARK_MYC_TARGETS_V21.0e-63.4e-4-0.018-0.350.0150.412.6e-40.0340.0260.226.7e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RSF1

BRCA0.430.430.40proteinmRNASCNVmethylationCCRCC0.30-0.130.140.000.19-0.18proteinmRNASCNVmethylationCOAD0.320.170.33proteinmRNASCNVmethylationGBM0.60-0.100.12-0.150.340.06proteinmRNASCNVmethylationHNSCC0.81-0.370.59-0.380.78-0.40proteinmRNASCNVmethylationLSCC0.55-0.320.53-0.430.63-0.44proteinmRNASCNVmethylationLUAD0.53-0.020.570.010.51-0.17proteinmRNASCNVmethylationOV0.620.600.59proteinmRNASCNVmethylationPDAC0.22-0.080.070.210.100.01proteinmRNASCNVmethylationUCEC0.43-0.220.11-0.060.11-0.28proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RSF1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.