Basic information
- Full name
- solute carrier family 12 member 2
- Ensembl
- ENSG00000064651.14
- Summary
- The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Annotation
- Druggable target (Tier T2)
Protein product
- ENST00000262461.7 Primary ENSP00000262461.2 (20 phosphosites)
- ENST00000343225.4
- ENST00000628403.2
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 0.65 | - | -0.12 | - | - | -0.16 | -6.2e-5 | 5.3e-8 | - | 0.011 | - |
protein | 2.4e-6 | - | -1.4e-9 | 1.1e-18 | - | -0.025 | - | 5.1e-9 | 0.87 | 2.1e-5 | 0.088 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SLC12A2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_PEROXISOME | 3.3e-7 | - | -0.011 | 0.015 | 0.23 | 0.37 | - | 0.14 | 3.1e-3 | 3.7e-5 | 1.1e-4 | |
PROGENy: Androgen | 4.6e-6 | - | 0.15 | -0.13 | 0.34 | 4.9e-5 | - | 0.053 | 0.81 | 0.014 | 7.7e-4 | |
HALLMARK_ANDROGEN_RESPONSE | 1.5e-5 | - | 0.099 | -0.079 | -0.5 | 2.4e-4 | - | 0.14 | 0.063 | 5.6e-3 | 1.2e-3 | |
HALLMARK_SPERMATOGENESIS | 2.4e-5 | - | 0.65 | 0.01 | 0.026 | 0.066 | - | 0.097 | 0.91 | 6.3e-3 | 0.71 | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 2.5e-4 | - | 0.9 | -0.87 | -0.039 | 8.8e-3 | - | 0.1 | 2.1e-3 | 0.019 | 5.5e-3 | |
HALLMARK_BILE_ACID_METABOLISM | 3.3e-4 | - | -0.038 | 0.061 | 0.062 | 0.93 | - | 0.27 | 0.5 | 4.1e-4 | 0.002 | |
Clinical: BMI | 4.5e-4 | - | 0.1 | - | 0.72 | 0.69 | - | 0.63 | - | 0.026 | 4.7e-4 | |
PROGENy: Estrogen | 7.8e-4 | - | 0.55 | -0.47 | -0.085 | 2.5e-3 | - | 0.063 | 0.13 | 0.096 | 9.8e-4 | |
HALLMARK_FATTY_ACID_METABOLISM | 0.009 | - | -0.17 | 0.052 | -0.93 | 0.4 | - | -0.78 | 0.29 | 2.4e-3 | 0.024 | |
HALLMARK_OXIDATIVE_PHOSPHORYLATION | 0.014 | - | -0.26 | 0.011 | 0.39 | -0.21 | - | 0.13 | 0.069 | 0.015 | 0.84 |
Cis-association
Associations between omics data of SLC12A2
Trans-association
Associations of the protein abundance of SLC12A2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.