Gene: SPR

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
sepiapterin reductase
Ensembl
ENSG00000116096.6
Summary
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.6e-6--7.3e-13--0.0151.5e-91.2e-22--0.72-
protein-8.4e-8--5.8e-14-0.032--6.5e-5-2.4e-81.7e-4-0.58-5.7e-32.8e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC5678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2323.52424.52525.52626.52727.52828.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer05101520253035400-5-10-15-20-25-30-35-40proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SPR with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM4.7e-191.8e-40.0170.19.8e-60.0160.967.7e-60.0344.6e-60.018
HALLMARK_PEROXISOME1.1e-183.4e-54.8e-30.0260.113.6e-30.0756.8e-48.9e-31.4e-50.039
HALLMARK_FATTY_ACID_METABOLISM2e-110.0750.077-0.0240.121.7e-51.3e-41.3e-30.364.1e-31.3e-3
HALLMARK_ESTROGEN_RESPONSE_EARLY6.6e-102.2e-160.490.0836.6e-40.250.650.530.410.0840.48
chromosomal instability9.1e-9-0.0191.9e-35.8e-50.893.3e-62.1e-5-0.441.8e-30.470.2
PERT-P100-DIA_STAUROSPORINE1.6e-72.3e-3--0.0260.370.251.2e-3-0.0330.25
KINASE-PSP_AMPKA1/PRKAA16.6e-7---7.3e-3----1.9e-40.028
HALLMARK_ESTROGEN_RESPONSE_LATE7.1e-75.7e-100.19-0.490.0219.7e-30.19-0.170.0990.0560.64
HALLMARK_XENOBIOTIC_METABOLISM1.2e-60.360.023-0.0620.0150.0190.0264.2e-3-0.993.9e-30.2
PROGENy: Estrogen1.5e-62.2e-160.34-0.430.650.061.1e-4-0.002-0.560.020.044
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SPR

BRCA0.69-0.15-0.11proteinmRNASCNVmethylationCCRCC0.76-0.130.26-0.140.28-0.07proteinmRNASCNVmethylationCOAD0.230.430.25proteinmRNASCNVmethylationGBM0.660.080.220.030.020.02proteinmRNASCNVmethylationHNSCC0.80-0.000.59-0.110.63-0.03proteinmRNASCNVmethylationLSCC0.86-0.160.61-0.220.60-0.25proteinmRNASCNVmethylationLUAD0.69-0.07-0.04-0.060.15-0.06proteinmRNASCNVmethylationOV0.660.040.07proteinmRNASCNVmethylationPDAC0.660.11-0.030.140.070.01proteinmRNASCNVmethylationUCEC0.76-0.04-0.05-0.060.120.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SPR and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.