SPR: sepiapterin reductase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1z6z chain A
1z6z chain B
1z6z chain C
1z6z chain D
1z6z chain E
1z6z chain F
4hwk chain A
4hwk chain B
4hwk chain C
4hwk chain D
4j7u chain A
4j7u chain B
4j7u chain C
4j7u chain D
4j7x chain A
4j7x chain B
4j7x chain F
4j7x chain J
4xwy chain A
4xwy chain B
4xwy chain C
4xwy chain D
4z3k chain A
4z3k chain B
4z3k chain C
4z3k chain D
6i6c chain A
6i6c chain B
6i6f chain A
6i6f chain B
6i6p chain A
6i6p chain B
6i6t chain A
6i6t chain B
6i6v chain A
6i6v chain B
6i79 chain A
6i79 chain B
6usn chain A
6usn chain B
6usn chain C
6usn chain D
7dsf chain A
7dsf chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S16 VCLLTGAS RGFGRTL 1 54 - - 29 25 - - - - - - - - - - - - - - - - S103 LLINNAGS LGDVSKG 10 1339 105 - 103 80 86 84 45 - 81 47 103 95 105 97 54 12 101 42 81 18 S145 VLKAFPDS PGLNRTV 9 664 96 - 96 73 - - 44 - 6 3 49 46 85 77 7 1 7 3 62 9 S213 QQLARETS VDPDMRK 7 592 45 - 95 72 - - 37 - - - 44 41 59 51 - - 82 37 24 5
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S16 VCLLTGAS RGFGRTL -0.042 - -0.042 - - - - - - - - S103 LLINNAGS LGDVSKG -1.4e-16 - -6.7e-8 -5e-7 - -6.5e-6 -5.0e-6 0.41 -0.02 -1.7e-3 0.46 S145 VLKAFPDS PGLNRTV -0.26 - 0.25 - - - -0.46 -0.018 - - - S213 QQLARETS VDPDMRK 5e-11 - 1.1e-9 - - - 4.8e-3 1.4e-9 - -0.067 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S16
S103
S145
S213
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S16 S103 S145 S213 protein RNA SCNV methylation CCRCC S16 S103 S145 S213 protein RNA SCNV methylation COAD S16 S103 S145 S213 protein RNA SCNV methylation GBM S16 S103 S145 S213 protein RNA SCNV methylation HNSCC S16 S103 S145 S213 protein RNA SCNV methylation LSCC S16 S103 S145 S213 protein RNA SCNV methylation LUAD S16 S103 S145 S213 protein RNA SCNV methylation OV S16 S103 S145 S213 protein RNA SCNV methylation PDAC S16 S103 S145 S213 protein RNA SCNV methylation UCEC S16 S103 S145 S213 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S16
S103
S145
S213
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S16
S103
S145
S213
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.