Gene: TLN1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
talin 1
Ensembl
ENSG00000137076.21
Summary
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Annotation
Ligand

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.5e-13-1.7e-3--1.4e-5-5.5e-28-2.3e-30--0.12-
protein-7.6e-36-2.5e-4-1.5e-24--5.8e-4-1.4e-34-1.3e-35-3e-71.8e-14-1.5e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7891011121314151617log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC27.52828.52929.53030.53131.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TLN1 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: StromalScore3.4e-1102.2e-161.6e-83.3e-92.2e-162.2e-162.2e-165.2e-102.2e-164.7e-42.2e-16
PROGENy: TGFb5.4e-892.2e-161.3e-92.4e-72.2e-71.4e-112.2e-166.6e-52.2e-163.9e-71.7e-10
HALLMARK_UV_RESPONSE_DN1.9e-859.1e-91.6e-92.0e-52.2e-162.2e-102.2e-161.4e-105e-97.5e-32.2e-16
ESTIMATE: ESTIMATEScore2.3e-852.2e-162.1e-33.5e-72.2e-162.5e-72.2e-162.2e-163.3e-100.212.2e-16
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION3.2e-832.2e-162.3e-42.4e-72.2e-163.4e-72.2e-165.1e-42.2e-168.1e-32.2e-16
xcell: stroma score1.9e-821.1e-52.2e-162.2e-161.7e-31.4e-52.2e-169.7e-101.6e-44.7e-102.2e-16
xcell: microenvironment score1.1e-697.0e-56.9e-46.1e-72.2e-168.1e-52.2e-162.2e-168.3e-56.3e-32.2e-16
HALLMARK_KRAS_SIGNALING_UP7.4e-652.2e-163.2e-53.3e-72.2e-169.0e-52.2e-168.1e-76.6e-90.758.8e-7
HALLMARK_MYOGENESIS9e-645.4e-54.4e-64e-87.2e-72.4e-61.6e-105.5e-92.7e-51.0e-62.2e-16
xcell: Cancer associated fibroblast1.3e-572.1e-52.5e-82.1e-110.621.2e-56.2e-163e-96.3e-35.9e-93.5e-11
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TLN1

BRCA0.390.070.13proteinmRNASCNVmethylationCCRCC0.50-0.000.35-0.210.25-0.03proteinmRNASCNVmethylationCOAD0.13-0.200.20proteinmRNASCNVmethylationGBM0.83-0.130.36-0.100.37-0.15proteinmRNASCNVmethylationHNSCC0.66-0.020.340.010.500.03proteinmRNASCNVmethylationLSCC0.73-0.100.36-0.010.600.06proteinmRNASCNVmethylationLUAD0.53-0.010.26-0.190.55-0.14proteinmRNASCNVmethylationOV0.350.350.38proteinmRNASCNVmethylationPDAC0.380.100.12-0.160.42-0.13proteinmRNASCNVmethylationUCEC0.63-0.100.07-0.090.33-0.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TLN1 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.