Basic information

Full name
TNF receptor superfamily member 17
Ensembl
ENSG00000048462.11
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Annotation
Cancer driver (Oncogene) Druggable target (Tier T1) Receptor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.6e-9-0.81--0.361.4e-77.7e-14--0.48-
protein0.018--3.9e-3---4.1e-33.9e-5---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCLSCCLUAD1717.51818.51919.52020.52121.52222.52323.524log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer01020304050607080901000-10-20-30-40-50-60-70-80-90-100proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TNFRSF17 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: StromalScore2.6e-60.0120.76---2.2e-60.065---
ESTIMATE: ESTIMATEScore5.0e-69.2e-30.78---9.6e-70.18---
xcell: B cell2.9e-50.30.16---4.2e-60.19---
PROGENy: TGFb2.9e-50.0850.28---3.1e-39.6e-3---
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION6.9e-50.120.75---1.3e-40.024---
xcell: microenvironment score9.9e-50.0420.89---2.4e-70.66---
ESTIMATE: ImmuneScore1.9e-40.030.97---3.5e-60.54---
HALLMARK_TNFA_SIGNALING_VIA_NFKB2.3e-48.7e-3-0.58---3.8e-50.24---
HALLMARK_TGF_BETA_SIGNALING3.0e-40.0660.59---1.6e-40.28---
PROGENy: NFkB4.2e-40.021-0.65---1.8e-40.15---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TNFRSF17

BRCA0.220.07-0.18proteinmRNASCNVmethylationCCRCC0.10-0.010.02proteinmRNASCNVmethylationCOAD-0.08proteinmRNASCNVmethylationGBM0.34proteinmRNASCNVmethylationHNSCC-0.10proteinmRNASCNVmethylationLSCC0.530.270.11proteinmRNASCNVmethylationLUAD0.12-0.02-0.01proteinmRNASCNVmethylationOV-0.11proteinmRNASCNVmethylationPDAC0.05proteinmRNASCNVmethylationUCEC0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TNFRSF17 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.