Gene: USP24

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
ubiquitin specific peptidase 24
Ensembl
ENSG00000162402.14
Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.3e-15--1.6e-18---0.078-1.4e-50.7--3.4e-3-
protein3.6e-3--0.670.78-0.064-1.9e-38.6e-6-0.960.141.9e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23.423.623.82424.224.424.624.82525.225.425.625.8log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer024681012140-2-4-6-8-10-12-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of USP24 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD4+ Th21.9e-120.0151.1e-40.172.4e-32.9e-30.0210.760.270.0523.7e-3
xcell: T cell gamma delta2.5e-8-0.923.5e-3-0.520.268e-83.8e-40.880.70.0110.019
xcell: T cell CD4+ memory1e-70.0590.007-0.61-0.452.9e-51.0e-56.8e-30.180.630.69
HALLMARK_IL6_JAK_STAT3_SIGNALING6.3e-70.130.010.69-0.48.3e-53.5e-40.77-0.191.8e-30.012
HALLMARK_ALLOGRAFT_REJECTION6.7e-70.084.9e-3-0.98-0.491.0e-42.6e-50.3-0.60.20.046
PROGENy: NFkB1.9e-60.660.0720.13-0.179.2e-45.2e-4-0.57-0.111.1e-61.5e-3
HALLMARK_INTERFERON_GAMMA_RESPONSE2.7e-60.0377.4e-4-0.72-0.0697.5e-33.1e-40.63-0.33.5e-33.5e-3
xcell: Class-switched memory B cell3.8e-60.0181.9e-30.780.370.0161.9e-40.960.32-0.470.13
xcell: immune score5.8e-60.0153.7e-4-0.95-0.611.5e-42.5e-40.19-0.170.410.49
xcell: Plasmacytoid dendritic cell5.9e-60.0180.560.410.563.8e-41.1e-5-0.320.68-0.937.2e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of USP24

BRCA0.550.550.48proteinmRNASCNVmethylationCCRCC0.41-0.080.27-0.000.30-0.10proteinmRNASCNVmethylationCOAD0.300.340.28proteinmRNASCNVmethylationGBM0.66-0.050.16-0.040.28-0.01proteinmRNASCNVmethylationHNSCC0.79-0.290.40-0.280.38-0.23proteinmRNASCNVmethylationLSCC0.79-0.040.59-0.120.64-0.12proteinmRNASCNVmethylationLUAD0.73-0.080.48-0.100.62-0.11proteinmRNASCNVmethylationOV0.450.270.33proteinmRNASCNVmethylationPDAC0.45-0.060.300.050.440.12proteinmRNASCNVmethylationUCEC0.710.100.190.110.19-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of USP24 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.