PRKACA: protein kinase cAMP-activated catalytic subunit alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2gu8 chain A
3agl chain A
3agl chain B
3agm chain A
3ama chain A
3amb chain A
3l9l chain A
3l9l chain B
3l9m chain A
3l9m chain B
3l9n chain A
3mvj chain A
3mvj chain B
3mvj chain E
3nx8 chain A
3oog chain A
3ovv chain A
3owp chain A
3oxt chain A
3p0m chain A
3poo chain A
3vqh chain A
4ae6 chain A
4ae6 chain B
4ae9 chain A
4ae9 chain B
4uj1 chain A
4uj2 chain A
4uj9 chain A
4uja chain A
4ujb chain A
4wb5 chain A
4wb6 chain A
4wb6 chain B
4wb7 chain A
4wb7 chain B
4wb8 chain A
5bx6 chain A
5bx7 chain A
5izf chain A
5izj chain A
5izj chain B
5j5x chain A
5n23 chain A
5uzk chain A
6byr chain A
6byr chain C
6bys chain A
6bys chain C
6bys chain E
6bys chain G
6c0u chain A
6frx chain A
6no7 chain A
6no7 chain C
6no7 chain E
6no7 chain G
6qj7 chain A
6wjf chain A
6wjf chain B
6wjg chain A
6wjg chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S11 AAAAKKGS EQESVKE 1 22 - - - - - - - - - - - - - - - - 17 5 - - S15 KKGSEQES VKEFLAK 5 367 - - - - - - 44 - - - 49 44 55 48 13 4 75 35 - - T49 DQFERIKT LGTGSFG 2 24 8 - - - - - - - - - - - - - 14 2 - - - - Y331 DTSNFDDY EEEEIRV 8 341 78 - 58 40 5 4 - - 5 3 25 23 34 34 - - 13 5 11 3 S339 EEEEIRVS INEKCGK 10 1124 69 - 27 23 97 100 99 - 72 43 98 90 73 70 21 4 105 44 71 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S11 AAAAKKGS EQESVKE - - - - - - - - - - - S15 KKGSEQES VKEFLAK -2.7e-13 - - - - - -6.7e-8 -0.11 - -1.3e-8 - T49 DQFERIKT LGTGSFG - - - - - - - - - - - Y331 DTSNFDDY EEEEIRV -1e-23 - -4.7e-12 - - - -6.0e-5 -1e-10 - - - S339 EEEEIRVS INEKCGK -1.5e-45 - -2.1e-6 -1.8e-17 - -2.2e-5 -4.1e-19 -1.8e-16 - -1.3e-3 0.69
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S11
S15
T49
Y331
S339
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S11 S15 T49 Y331 S339 protein RNA SCNV methylation CCRCC S11 S15 T49 Y331 S339 protein RNA SCNV methylation COAD S11 S15 T49 Y331 S339 protein RNA SCNV methylation GBM S11 S15 T49 Y331 S339 protein RNA SCNV methylation HNSCC S11 S15 T49 Y331 S339 protein RNA SCNV methylation LSCC S11 S15 T49 Y331 S339 protein RNA SCNV methylation LUAD S11 S15 T49 Y331 S339 protein RNA SCNV methylation OV S11 S15 T49 Y331 S339 protein RNA SCNV methylation PDAC S11 S15 T49 Y331 S339 protein RNA SCNV methylation UCEC S11 S15 T49 Y331 S339 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S11
S15
T49
Y331
S339
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S11
S15
T49
Y331
S339
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.