Protein: ENSP00000333896
Gene: RPS6KA4

LinkedOmicsKB © 2022-2023 Zhang Lab

RPS6KA4:
ribosomal protein S6 kinase A4

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T22RITEANLTGHEEKVS1076117-86651179-2717103947264561245224113
S171LENVLLDSEGHIVLT119----------109--------
S196EEKERTFSFCGTIEY833417-88171035-5732353239386-----
T200RTFSFCGTIEYMAPE218----------5454------
Y203SFCGTIEYMAPEIIR19------------54------
S251RNTQAEVSRRILKCS341----------10988----6-
S324PFRPQIRSELDVGNF328------9---5554------
Y342FTRLEPVYSPPGSPP25124-------1710----------
S343TRLEPVYSPPGSPPP1053734-88302437-4429547468429269779
S347PVYSPPGSPPPGDPR101472113-9976939599-10762108999790781595398918
Showing 1 to 10 of 25 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T22RITEANLTGHEEKVS-1.2e-10--0.016--0.29-7.4e-8-9.8e-3-6.1e-3-0.88-1.3e-6
S171LENVLLDSEGHIVLT-----------
S196EEKERTFSFCGTIEY-7.8e-4-----0.25-7.1e-4-0.2---
T200RTFSFCGTIEYMAPE-----------
Y203SFCGTIEYMAPEIIR-----------
S251RNTQAEVSRRILKCS-----------
S324PFRPQIRSELDVGNF-----------
Y342FTRLEPVYSPPGSPP-----------
S343TRLEPVYSPPGSPPP0.14--0.024-0.85-0.91---
S347PVYSPPGSPPPGDPR-0.34-8.7e-4-5.4e-3--1.6e-30.29-0.540.72-0.250.81
Showing 1 to 10 of 25 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationCCRCCT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationCOADT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationGBMT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationHNSCCT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationLSCCT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationLUADT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationOVT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationPDACT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylationUCECT22S171S196T200Y203S251S324Y342S343S347Y359S360S365S433T542S634S678S681S682T687S693S721S737S745proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.