Basic information
- Full name
- ribosomal protein S6 kinase A4
- Ensembl
- ENSG00000162302.13
- Summary
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
- Annotation
- Druggable target (Tier T4) Protein Kinase
Protein product
- ENST00000334205.9 Primary ENSP00000333896.4 (25 phosphosites)
- ENST00000528057.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 6.2e-51 | - | 1.4e-24 | - | - | 2.8e-8 | 2.4e-10 | 1.3e-13 | - | 5.4e-5 | - |
protein | 2.2e-14 | - | 1.2e-21 | 2.5e-9 | - | 1.1e-6 | -0.073 | 0.64 | -0.92 | 1.4e-14 | -4.1e-7 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of RPS6KA4 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_INTERFERON_GAMMA_RESPONSE | 2.5e-19 | 0.097 | 1.9e-3 | 0.19 | 2.4e-5 | 1.4e-5 | 3.1e-7 | 6.2e-3 | 0.033 | 0.45 | 2.3e-3 | |
PROGENy: JAK-STAT | 5.3e-19 | 0.12 | 8.9e-5 | 0.099 | 2.4e-4 | 4.0e-4 | 3.1e-8 | 2.5e-3 | 0.079 | 0.064 | 0.096 | |
HALLMARK_INTERFERON_ALPHA_RESPONSE | 1.1e-17 | 0.22 | 1.2e-3 | 0.16 | 2.8e-4 | 2.4e-5 | 4.2e-8 | 4.4e-3 | 0.16 | 0.22 | 0.018 | |
ESTIMATE: ImmuneScore | 1.3e-16 | 0.047 | 1.8e-3 | 0.56 | 2.8e-7 | 5.7e-4 | 7.2e-4 | 0.022 | 0.011 | -0.94 | 1.6e-4 | |
HALLMARK_ALLOGRAFT_REJECTION | 1e-15 | 0.092 | 6.6e-3 | 0.48 | 4.1e-6 | 6.4e-5 | 4.0e-4 | 0.016 | 0.063 | 0.76 | 4.0e-4 | |
xcell: microenvironment score | 1.2e-14 | 0.063 | 0.013 | -0.88 | 6.7e-5 | 0.016 | 0.012 | 6.9e-4 | 2.1e-3 | 0.92 | 2.3e-6 | |
ESTIMATE: ESTIMATEScore | 6.1e-14 | 0.021 | 2.3e-3 | -0.83 | 3.3e-6 | 5.3e-3 | 3.3e-3 | 0.023 | 0.048 | -0.33 | 7.6e-7 | |
xcell: immune score | 1.1e-13 | 0.034 | 0.11 | -0.78 | 7.8e-5 | 0.002 | 5.7e-3 | 1.3e-3 | 2.1e-4 | 0.39 | 0.012 | |
xcell: T cell CD8+ central memory | 1.3e-13 | 0.064 | 6.5e-4 | 0.085 | 0.029 | 2.1e-3 | 2.7e-3 | 8.9e-5 | 0.18 | 0.36 | 0.046 | |
xcell: Myeloid dendritic cell activated | 1.3e-12 | 0.027 | 2.9e-3 | 0.82 | 4.4e-3 | 0.027 | 0.023 | 1.4e-5 | 0.047 | 0.5 | 7.4e-3 |
Cis-association
Associations between omics data of RPS6KA4
Trans-association
Associations of the protein abundance of RPS6KA4 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.