Basic information

Full name
ribosomal protein S6 kinase A4
Ensembl
ENSG00000162302.13
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Annotation
Druggable target (Tier T4) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA6.2e-51-1.4e-24--2.8e-82.4e-101.3e-13-5.4e-5-
protein2.2e-14-1.2e-212.5e-9-1.1e-6-0.0730.64-0.921.4e-14-4.1e-7

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC6.577.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of RPS6KA4 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_INTERFERON_GAMMA_RESPONSE2.5e-190.0971.9e-30.192.4e-51.4e-53.1e-76.2e-30.0330.452.3e-3
PROGENy: JAK-STAT5.3e-190.128.9e-50.0992.4e-44.0e-43.1e-82.5e-30.0790.0640.096
HALLMARK_INTERFERON_ALPHA_RESPONSE1.1e-170.221.2e-30.162.8e-42.4e-54.2e-84.4e-30.160.220.018
ESTIMATE: ImmuneScore1.3e-160.0471.8e-30.562.8e-75.7e-47.2e-40.0220.011-0.941.6e-4
HALLMARK_ALLOGRAFT_REJECTION1e-150.0926.6e-30.484.1e-66.4e-54.0e-40.0160.0630.764.0e-4
xcell: microenvironment score1.2e-140.0630.013-0.886.7e-50.0160.0126.9e-42.1e-30.922.3e-6
ESTIMATE: ESTIMATEScore6.1e-140.0212.3e-3-0.833.3e-65.3e-33.3e-30.0230.048-0.337.6e-7
xcell: immune score1.1e-130.0340.11-0.787.8e-50.0025.7e-31.3e-32.1e-40.390.012
xcell: T cell CD8+ central memory1.3e-130.0646.5e-40.0850.0292.1e-32.7e-38.9e-50.180.360.046
xcell: Myeloid dendritic cell activated1.3e-120.0272.9e-30.824.4e-30.0270.0231.4e-50.0470.57.4e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of RPS6KA4

BRCA0.380.190.32proteinmRNASCNVmethylationCCRCC0.340.110.07-0.060.06-0.01proteinmRNASCNVmethylationCOAD0.430.230.23proteinmRNASCNVmethylationGBM0.69-0.190.17-0.150.21-0.00proteinmRNASCNVmethylationHNSCC0.800.060.35-0.020.39-0.03proteinmRNASCNVmethylationLSCC0.65-0.120.35-0.140.300.02proteinmRNASCNVmethylationLUAD0.520.050.31-0.200.39-0.03proteinmRNASCNVmethylationOV0.350.330.24proteinmRNASCNVmethylationPDAC0.480.160.10-0.020.39-0.02proteinmRNASCNVmethylationUCEC0.37-0.000.13-0.190.38-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of RPS6KA4 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.