Protein: ENSP00000354201
Gene: UBE2Z

LinkedOmicsKB © 2022-2023 Zhang Lab

UBE2Z:
ubiquitin conjugating enzyme E2 Z

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S337NENAEMDSDSSSSGT45917-----27-----4371----
S339NAEMDSDSSSSGTET22417-----------43------
S340AEMDSDSSSSGTETD22417-----------43------
Showing 1 to 3 of 3 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S337NENAEMDSDSSSSGT-----------
S339NAEMDSDSSSSGTET-----------
S340AEMDSDSSSSGTETD-----------
Showing 1 to 3 of 3 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_JNK1/MAPK8S3370.003---0.003------
cibersort: Myeloid dendritic cell restingS3397.4e-37.4e-3---------
cibersort: Myeloid dendritic cell restingS3407.4e-37.4e-3---------
cibersort: Myeloid dendritic cell restingS3379.2e-37.4e-3--0.31------
PERT-P100-DIA_STAUROSPORINES3370.0150.035--0.18------
cibersort: T cell CD8+S3370.0220.12--0.09------
KINASE-PSP_Akt1/AKT1S3400.0350.035---------
PERT-P100-DIA_STAUROSPORINES3400.0350.035---------
KINASE-PSP_Akt1/AKT1S3390.0350.035---------
PERT-P100-DIA_STAUROSPORINES3390.0350.035---------
Showing 1 to 10 of 774 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS337S339S340proteinRNASCNVmethylationCCRCCS337S339S340proteinRNASCNVmethylationCOADS337S339S340proteinRNASCNVmethylationGBMS337S339S340proteinRNASCNVmethylationHNSCCS337S339S340proteinRNASCNVmethylationLSCCS337S339S340proteinRNASCNVmethylationLUADS337S339S340proteinRNASCNVmethylationOVS337S339S340proteinRNASCNVmethylationPDACS337S339S340proteinRNASCNVmethylationUCECS337S339S340proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
CDK4S3396.7e-36.7e-3---------
CDK4S3406.7e-36.7e-3---------
LCKS3400.0090.009---------
LCKS3390.0090.009---------
WNK3S3379.8e-3---9.8e-3------
STRADBS3370.019---0.019------
ADCK2S3400.0220.022---------
ADCK2S3390.0220.022---------
ADCK2S3370.0220.022---------
PBKS3370.0230.087--0.13------
Showing 1 to 10 of 1614 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PLPP2S337-3.4e-3-3.4e-3---------
PLPP2S339-3.4e-3-3.4e-3---------
PLPP2S340-3.4e-3-3.4e-3---------
PPIP5K2S340-6.2e-3-6.1e-3---------
PPIP5K2S339-6.2e-3-6.1e-3---------
PUDPS337-0.013-0.091---0.069------
OCRLS337-0.015-0.6---3.4e-3------
MTM1S337-0.018-0.29---0.022------
PTPN12S340-0.018-0.019---------
PTPN12S339-0.018-0.019---------
Showing 1 to 10 of 720 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.