ACVRL1: activin A receptor like type 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2lcr chain A
3my0 chain A
3my0 chain B
3my0 chain C
3my0 chain D
3my0 chain E
3my0 chain F
3my0 chain G
3my0 chain H
3my0 chain I
3my0 chain J
3my0 chain K
3my0 chain L
3my0 chain M
3my0 chain N
3my0 chain O
3my0 chain P
3my0 chain Q
3my0 chain R
3my0 chain S
3my0 chain T
3my0 chain U
3my0 chain V
3my0 chain W
3my0 chain X
4fao chain C
4fao chain D
4fao chain I
4fao chain J
4fao chain O
4fao chain P
4fao chain U
4fao chain V
4fao chain c
4fao chain d
4fao chain i
4fao chain j
6sf1 chain A
6sf2 chain A
6sf2 chain D
6sf3 chain A
7ppc chain E
7ppc chain F
7ppc chain G
7ppc chain H
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S155 EKQRGLHS ELGESSL 2 219 - - - - - - - - - - 83 77 32 27 - - - - - - S160 LHSELGES SLILKAS 10 1184 73 - 94 74 88 91 90 - 79 44 98 89 92 84 21 4 84 34 30 15 S161 HSELGESS LILKASE 10 812 27 - 61 50 54 54 35 - 61 35 94 86 66 61 8 1 58 23 25 13 S172 KASEQGDS MLGDLLD 1 27 - - - - - - - - - - 14 13 - - - - - - - - S493 KKTLQKIS NSPEKPK 2 116 - - - - - - 54 - - - - - - - - - - - 58 4 S495 TLQKISNS PEKPKVI 5 206 - - - - - - 9 - - - 73 67 12 12 - - 15 9 - 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S155 EKQRGLHS ELGESSL -1.6e-41 - - - - - -1e-27 -2.9e-16 - - - S160 LHSELGES SLILKAS -1.6e-43 - 1.9e-12 -4.5e-25 - -9e-9 -5.1e-32 -3.1e-29 - -0.14 -2.1e-3 S161 HSELGESS LILKASE -7e-27 - 1.5e-4 -1.3e-10 - -0.028 -1.6e-30 -9.6e-21 - -0.41 -0.056 S172 KASEQGDS MLGDLLD - - - - - - - - - - - S493 KKTLQKIS NSPEKPK - - - - - - - - - - - S495 TLQKISNS PEKPKVI -6e-24 - - - - - -6.1e-24 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S155
S160
S161
S172
S493
S495
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation CCRCC S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation COAD S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation GBM S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation HNSCC S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation LSCC S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation LUAD S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation OV S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation PDAC S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation UCEC S155 S160 S161 S172 S493 S495 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S155
S160
S161
S172
S493
S495
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S155
S160
S161
S172
S493
S495
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.