Basic information

Full name
activin A receptor like type 1
Ensembl
ENSG00000139567.13
Summary
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T3) Protein Kinase Receptor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.5e-24-2.1e-18---5.2e-4-2e-34-6.7e-36--4.2e-3-
protein-9.6e-51---9e-9---9.8e-34-4.9e-30--0.47-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC67891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADPDACUCEC121314151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer0204060801001201400-20-40-60-80-100-120-140proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ACVRL1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_KRAS_SIGNALING_UP1.9e-70.0990.280.1--2.2e-40.018-0.021-
PATH-NP_TIE2_PATHWAY1.4e-5-----1.4e-5----
HALLMARK_COAGULATION1.7e-50.810.820.12--2.0e-40.11-1.3e-3-
xcell: Endothelial cell4.1e-50.490.590.1--7.2e-40.087-0.038-
ESTIMATE: ESTIMATEScore4.2e-50.460.450.089--3.7e-30.12-0.017-
cibersort: Neutrophil6.1e-50.520.120.11--0.0460.25-0.004-
HALLMARK_IL2_STAT5_SIGNALING6.6e-50.690.740.13--6.4e-30.021-0.013-
HALLMARK_INFLAMMATORY_RESPONSE6.9e-50.980.640.071--4.4e-30.11-2.6e-3-
HALLMARK_COMPLEMENT7.9e-50.750.660.25--0.0060.069-1.5e-3-
HALLMARK_TNFA_SIGNALING_VIA_NFKB1.6e-40.980.480.043--3.7e-30.087-0.058-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ACVRL1

BRCA0.120.310.23proteinmRNASCNVmethylationCCRCC0.29-0.58-0.10-0.38-0.210.18proteinmRNASCNVmethylationCOAD0.28-0.080.11proteinmRNASCNVmethylationGBM0.050.23-0.05proteinmRNASCNVmethylationHNSCC-0.170.020.07proteinmRNASCNVmethylationLSCC0.42-0.19-0.10-0.21-0.240.06proteinmRNASCNVmethylationLUAD0.22-0.10-0.010.120.030.22proteinmRNASCNVmethylationOV0.05proteinmRNASCNVmethylationPDAC0.47-0.400.04-0.180.060.04proteinmRNASCNVmethylationUCEC-0.350.16-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ACVRL1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.