SMG1: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6l53 chain A
6l54 chain A
6syt chain A
6z3r chain A
7pw4 chain A
7pw5 chain A
7pw6 chain A
7pw7 chain A
7pw8 chain A
7pw9 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S11 RAPGSRLS SGGGGGG 3 29 8 - - - - - - - - - - - 8 8 - - 3 2 - - S34 DWQPRTDS ASADPDN 8 274 8 - - - 25 20 72 - 24 13 5 5 4 4 - - 24 8 49 13 S36 QPRTDSAS ADPDNLK 5 62 18 - 4 4 5 4 - - - - 10 8 5 4 - - - - - - S53 SSRDRGGS SSYGLQP 1 9 - - - - - - - - - - - - - - 8 1 - - - - S103 ENTYGRKS LGQELRV 2 13 - - - - - - - - - - - - - - 8 1 - - 4 - S115 LRVNNVTS PEFTSVQ 2 88 - - - - - - 36 - - - - - - - 43 9 - - - - S142 KSQERSMS YSDESRL 3 57 - - - - - - 18 - - - - - - - 15 3 - - 19 2 S1218 HDLKKSTS STSLNLK 3 40 - - - - - - - - - - 10 9 5 4 - - - - 12 - S1219 DLKKSTSS TSLNLKA 1 8 - - - - - - - - - - - - - - - - - - 8 - S1279 KLLPNMLS PDPRELQ 3 23 - - - - - - - - - - 5 4 - - 6 2 - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S11 RAPGSRLS SGGGGGG - - - - - - - - - - - S34 DWQPRTDS ASADPDN 2.3e-4 - - 0.028 - 1.5e-6 - - - - -0.53 S36 QPRTDSAS ADPDNLK - - - - - - - - - - - S53 SSRDRGGS SSYGLQP - - - - - - - - - - - S103 ENTYGRKS LGQELRV - - - - - - - - - - - S115 LRVNNVTS PEFTSVQ - - - - - - - - - - - S142 KSQERSMS YSDESRL - - - - - - - - - - - S1218 HDLKKSTS STSLNLK - - - - - - - - - - - S1219 DLKKSTSS TSLNLKA - - - - - - - - - - - S1279 KLLPNMLS PDPRELQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S11
S34
S36
S53
S103
S115
S142
S1218
S1219
S1279
S1897
S1903
S1907
S1910
T2239
S2267
S2271
T2291
S3512
S3515
T3519
T3522
S3527
T3529
T3550
S3556
T3569
S3570
T3573
T3577
S3584
S3588
S3632
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation CCRCC S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation COAD S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation GBM S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation HNSCC S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation LSCC S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation LUAD S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation OV S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation PDAC S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation UCEC S11 S34 S36 S53 S103 S115 S142 S1218 S1219 S1279 S1897 S1903 S1907 S1910 T2239 S2267 S2271 T2291 S3512 S3515 T3519 T3522 S3527 T3529 T3550 S3556 T3569 S3570 T3573 T3577 S3584 S3588 S3632 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S11
S34
S36
S53
S103
S115
S142
S1218
S1219
S1279
S1897
S1903
S1907
S1910
T2239
S2267
S2271
T2291
S3512
S3515
T3519
T3522
S3527
T3529
T3550
S3556
T3569
S3570
T3573
T3577
S3584
S3588
S3632
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S11
S34
S36
S53
S103
S115
S142
S1218
S1219
S1279
S1897
S1903
S1907
S1910
T2239
S2267
S2271
T2291
S3512
S3515
T3519
T3522
S3527
T3529
T3550
S3556
T3569
S3570
T3573
T3577
S3584
S3588
S3632
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.