Basic information
- Full name
- SMG1 nonsense mediated mRNA decay associated PI3K related kinase
- Ensembl
- ENSG00000157106.17
- Summary
- This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
- Annotation
- Essential genes Druggable target (Tier T3) Protein Kinase
Protein product
- ENST00000446231.7 Primary ENSP00000402515.3 (33 phosphosites)
- ENST00000565224.5
- ENST00000330588.4
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 3.6e-16 | - | -1.1e-3 | - | - | 8.9e-5 | 4.1e-16 | 1.5e-10 | - | 2.5e-3 | - |
protein | 1.8e-35 | - | 1.2e-22 | -5.3e-3 | - | 3e-21 | 1.8e-28 | 6.9e-19 | -8.8e-3 | -0.82 | 0.11 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SMG1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_G2M_CHECKPOINT | 1.2e-23 | 1.8e-4 | 2.1e-7 | -0.38 | 4.8e-7 | 0.046 | 5.0e-5 | 5.1e-3 | 0.086 | 2.0e-5 | 1.6e-4 | |
HALLMARK_E2F_TARGETS | 4.8e-23 | 1.4e-3 | 2.2e-7 | -0.49 | 7.5e-7 | 0.078 | 2.3e-4 | 5.3e-3 | 0.063 | 7.3e-6 | 5.2e-5 | |
HALLMARK_MYC_TARGETS_V2 | 1.2e-19 | 5.1e-3 | 7.0e-6 | 0.85 | 5.8e-5 | 3.1e-4 | 2.2e-3 | 0.19 | 0.024 | 6.7e-4 | 4.0e-4 | |
KINASE-PSP_CDK1 | 2.3e-19 | 1.7e-4 | 4.1e-3 | -0.96 | 1.4e-3 | 1.0e-6 | 6.1e-3 | 1.7e-3 | 0.05 | 4.2e-4 | 0.016 | |
PROGENy: PI3K | 1.3e-15 | 6.9e-3 | 0.21 | 0.49 | 8.7e-6 | 2.2e-16 | 0.29 | 0.047 | 0.13 | 0.047 | 0.16 | |
KINASE-PSP_CDK2 | 2.2e-14 | 6.0e-4 | 4.3e-4 | -0.091 | 1.0e-5 | 0.018 | 0.079 | 3.9e-3 | 0.049 | 8.5e-4 | 0.031 | |
HALLMARK_MYC_TARGETS_V1 | 7.2e-14 | 0.03 | 6.9e-5 | -0.61 | 0.071 | 8.7e-5 | 5.6e-3 | 0.074 | 0.36 | 2.4e-4 | 1.6e-3 | |
HALLMARK_DNA_REPAIR | 1.5e-13 | 0.29 | 6.4e-5 | -0.27 | 1.4e-3 | 7.1e-9 | 1.7e-3 | 0.58 | 0.52 | 6.9e-5 | 0.037 | |
HALLMARK_MITOTIC_SPINDLE | 9.6e-13 | 2.4e-5 | 0.038 | 0.29 | 4.6e-5 | 0.45 | 0.2 | 0.001 | -0.87 | 9.4e-3 | 7.8e-4 | |
chromosomal instability | 1.2e-11 | 4.7e-4 | 2.3e-6 | 0.047 | 0.03 | 0.66 | 9.8e-3 | 0.055 | 0.011 | -0.45 | 0.019 |
Cis-association
Associations between omics data of SMG1
Trans-association
Associations of the protein abundance of SMG1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.